Description

Thymidine-3',5'-Diphosphate, Disodium Salt is a high-purity nucleotide derivative, essential for biochemical research and pharmaceutical development. This compound serves as a critical building block and substrate in enzymatic studies, particularly those involving DNA polymerases, kinases, and other nucleotide-processing enzymes. It is primarily utilized by researchers and manufacturers in the fields of molecular biology, diagnostic assay development, and nucleotide-based therapeutic synthesis.

Application

• Enzymology Research: As a specific substrate for studying the activity and kinetics of DNA polymerases, reverse transcriptases, and other nucleic acid enzymes.
• Diagnostic Reagent Manufacturing: A key component in the synthesis of probes and reagents for molecular diagnostics, including PCR and sequencing kits.
• Biochemical Synthesis: Used as a precursor or intermediate in the chemical and enzymatic synthesis of modified nucleotides, oligonucleotides, and their analogs.
• Cell Signaling Studies: Investigation of nucleotide-mediated signaling pathways and the role of specific dinucleotides in cellular processes.
• Pharmaceutical Development: Serves as a starting material or reference standard in the research and quality control of antiviral or anticancer nucleotide drugs.
• Academic Research: A fundamental tool for universities and research institutes conducting basic research in genetics, biochemistry, and molecular biology.

Basic Information

Product Name	Thymidine-3',5'-Diphosphate, Disodium Salt
CAS No.	108322-12-9
Molecular Formula	C10H13N2Na2O11P2
Molecular Weight	464.14 g/mol
Synonyms	3',5'-dTDP disodium salt; Thymidine 3',5'-diphosphate disodium; TDP disodium; dTDP disodium salt; 2'-Deoxythymidine 3',5'-diphosphate disodium salt; pdTp disodium; Thymidine 3',5'-bisphosphate disodium salt
EINECS	Contact for details

Quality Control

Our Thymidine-3',5'-Diphosphate, Disodium Salt is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
pH (1% Solution)	6.0 - 8.0
Endotoxin (LAL)	< 10 EU/mg (if applicable)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.