Description

Cyclohexanecarbonyl Chloride, 5-Methyl-2-(1-Methylethyl)-, (1R,2S,5R)- (9Ci) is a high-purity, stereochemically defined chiral building block essential for advanced organic synthesis. Its value lies in its role as a key intermediate for constructing complex molecules with precise three-dimensional architecture, critical for developing active pharmaceutical ingredients (APIs) and specialty agrochemicals. This compound is primarily needed by research and development chemists, process development scientists, and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries seeking to introduce the (-)-menthyl carbonyl moiety into target structures.

Application

• Pharmaceutical Intermediate: Serves as a crucial chiral synthon for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) and anti-inflammatory agents.
• Agrochemical Synthesis: Used in the production of advanced, stereoselective pesticides and herbicides where the specific stereochemistry influences biological activity and environmental profile.
• Asymmetric Catalysis Ligand Precursor: Acts as a starting material for synthesizing chiral ligands and auxiliaries used in enantioselective catalytic reactions.
• Flavor and Fragrance Chemistry: Employed in the research and synthesis of high-value, natural-identical aroma chemicals and flavor compounds with specific olfactory properties.
• Academic and Industrial R&D: A valuable reagent for methodological development in organic synthesis, enabling studies on stereocontrolled acylation and subsequent functional group transformations.
• Peptide Mimetics and Prodrug Design: Utilized to introduce lipophilic, chiral carboxylic acid derivatives into peptide backbones or as a pro-moiety in prodrug strategies to enhance bioavailability.

Basic Information

Item	Detail
Product Name	Cyclohexanecarbonyl Chloride, 5-Methyl-2-(1-Methylethyl)-, (1R,2S,5R)- (9Ci)
CAS No.	108235-80-9
Molecular Formula	C11H19ClO
Molecular Weight	202.72 g/mol
Synonyms	(-)-Menthyl chloroformate; (1R,2S,5R)-5-Methyl-2-(1-methylethyl)cyclohexanecarbonyl chloride; L-Menthyl chloroformate; (1R,2S,5R)-(-)-Menthyl chloroformate; (-)-Menthyl chlorocarbonate; (1R,2S,5R)-Menthyloxycarbonyl chloride; [1R-(1α,2β,5α)]-5-Methyl-2-(1-methylethyl)cyclohexanecarbonyl chloride
EINECS	Contact for details

Quality Control

Our Cyclohexanecarbonyl Chloride, 5-Methyl-2-(1-Methylethyl)-, (1R,2S,5R)- (9Ci) is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for sensitive synthetic applications. Certificates of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles are provided with every shipment to guarantee traceability and consistency for your critical processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature and reactivity as an acid chloride, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from moisture, strong bases, and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.