Description

1β,3α,7β-Trihydroxy-5β-Cholanic Acid is a key bile acid derivative and an important intermediate in the synthesis of ursodeoxycholic acid (UDCA) and other therapeutic agents. This compound matters for its role as a high-purity building block in pharmaceutical research and manufacturing, enabling the development of treatments for hepatobiliary disorders. It is primarily needed by pharmaceutical companies, research institutions, and fine chemical manufacturers focused on developing liver-protective drugs and advanced cholic acid derivatives.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of Ursodeoxycholic Acid (UDCA), a primary medication for gallstone dissolution and primary biliary cholangitis.
• Research & Development: Used as a reference standard and starting material in medicinal chemistry for developing novel bile acid analogs and hepatoprotective agents.
• Biochemical Studies: Employed in metabolic pathway research to study bile acid synthesis, transport, and their role in cholesterol homeostasis.
• Fine Chemical Synthesis: Serves as a chiral template for the production of other specialized steroidal compounds and high-value chemical entities.

Basic Information

Product Name	1β,3α,7β-Trihydroxy-5β-Cholanic Acid
CAS No.	108179-87-9
Molecular Formula	C₂₄H₄₀O₅
Molecular Weight	408.57 g/mol
Synonyms	3α,7β,12α-Trihydroxy-5β-cholan-24-oic Acid; 3α,7β,12α-Trihydroxy-5β-cholanoic Acid; 7β-Hydroxycholic Acid; 7β-HCA; 1β,3α,7β-Trihydroxy-5β-Cholan-24-Oic Acid; (3α,5β,7β,12α)-3,7,12-Trihydroxycholan-24-oic Acid; Ursodeoxycholic Acid Intermediate; UDCA Precursor
EINECS	Contact for details

Quality Control

Our 1β,3α,7β-Trihydroxy-5β-Cholanic Acid is produced under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical intermediate applications. Certificates of Analysis (COA) detailing purity, related substances, and residual solvents are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.