Description

β-Hydroxy Thyroxine is a chemically modified derivative of the thyroid hormone thyroxine (T4), characterized by the introduction of a β-hydroxy group. This structural modification is of significant interest for research into thyroid hormone metabolism, receptor binding affinity, and the development of novel biochemical tools. It serves as a critical intermediate and reference standard in pharmaceutical research and development, particularly for studies related to endocrine function and metabolic pathways. Key users include research institutions, pharmaceutical companies, and contract research organizations (CROs) engaged in advanced endocrinology and drug discovery programs.

Application

• Pharmaceutical Reference Standard: Used as a high-purity calibrant in analytical methods (HPLC, LC-MS) for quantifying thyroxine and its metabolites.
• Endocrinology Research: A vital biochemical tool for investigating thyroid hormone synthesis, secretion, metabolism, and degradation pathways in vitro and in vivo.
• Drug Discovery & Development: Serves as a key intermediate or active pharmaceutical ingredient (API) precursor in the synthesis of novel thyroid hormone analogs and potential therapeutics.
• Biochemical Assays: Employed in receptor binding studies to assess the affinity and activity of thyroid hormone receptor (TR) ligands.
• Metabolic Studies: Utilized to explore the impact of structural modifications on the hormonal activity, distribution, and clearance of thyroxine derivatives.

Basic Information

Product Name	β-Hydroxy Thyroxine
CAS No.	107849-54-7
Molecular Formula	C15H11I4NO5
Molecular Weight	776.86 g/mol
Synonyms	β-Hydroxy Thyroxine; β-Hydroxy-L-thyroxine; 3,5,3',5'-Tetraiodo-β-hydroxy-L-thyronine; O-(4-Hydroxy-3,5-diiodophenyl)-3,5-diiodo-β-hydroxy-L-tyrosine; Thyroxine β-hydroxy derivative; T4 β-hydroxy derivative
EINECS	Contact for details

Quality Control

Our β-Hydroxy Thyroxine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and support our products with a detailed Certificate of Analysis (COA) that includes results from advanced techniques such as HPLC for assay and related substances, IR for identification, and residual solvent analysis. Our quality commitment aligns with the standards expected for research-grade biochemicals and pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. The product is light-sensitive and should be handled under appropriate conditions to maintain stability. Keep the container in a dry, cool, and well-ventilated area.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Loss on Drying	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.