Description

2-Thiopheneacetyl Fluoride, 5-Nitro-α-Oxo- (9Ci) is a specialized fluorinated heterocyclic building block of significant interest in advanced organic synthesis. This compound matters for its role as a key precursor in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, where its unique thiophene and nitro-oxo-acetyl fluoride structure enables precise molecular modifications. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing complex molecules.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting various therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of new pesticides and herbicides, leveraging its reactive fluoride group for efficient coupling reactions.
• Material Science Research: Serves as a monomer or functionalization agent in the development of advanced polymers and functional materials with specific electronic properties.
• Chemical Biology Probes: Employed in the creation of activity-based probes and other tools for studying biological processes and enzyme mechanisms.
• Fluorination Reagent: Acts as a source of the acetyl fluoride moiety for introducing fluorocarbonyl groups into target molecules under mild conditions.
• Heterocyclic Chemistry: A valuable substrate for exploring new reactions and synthesizing diverse libraries of thiophene-containing compounds for screening.

Basic Information

Product Name	2-Thiopheneacetyl Fluoride, 5-Nitro-α-Oxo- (9Ci)
CAS No.	107748-18-5
Molecular Formula	C7H4FNO4S
Molecular Weight	217.17 g/mol
Synonyms	5-Nitro-2-thiopheneacetyl fluoride, α-oxo-; 2-Thiopheneacetyl fluoride, 5-nitro-α-oxo-; 5-Nitro-2-thiopheneglyoxyloyl fluoride; (5-Nitro-2-thienyl)oxoacetyl fluoride; 2-(5-Nitrothiophen-2-yl)-2-oxoacetyl fluoride; 5-Nitrothiophene-2-glyoxyloyl fluoride; α-Oxo-5-nitro-2-thiopheneacetyl fluoride
EINECS	Contact for details

Quality Control

Our 2-Thiopheneacetyl Fluoride, 5-Nitro-α-Oxo- (9Ci) is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical characterization, including HPLC, NMR, and MS, to verify identity and purity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes. We support cGMP compliance for advanced applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong acids and incompatible organic solvents.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.