Description

R-(-)-Mecamylamine Hydrochloride is the pure enantiomeric salt form of the nicotinic acetylcholine receptor (nAChR) antagonist, mecamylamine. This high-purity chiral compound is critical for research requiring stereospecific activity, particularly in neuroscience and pharmacology. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and fine chemical manufacturers focused on developing or studying neurological therapeutics and receptor-specific probes.

Application

• Neurological Research: As a selective non-competitive antagonist for neuronal-type nicotinic acetylcholine receptors (nAChRs) in preclinical studies.
• Pharmacology Reference Standard: Used in bioassays and analytical method development for quantifying mecamylamine activity.
• Pharmaceutical Intermediate: Serves as a key chiral building block in the synthesis of advanced investigational drugs targeting the central nervous system.
• Mechanistic Studies: Employed to investigate the role of nAChRs in various disease models, including addiction, pain, and cognitive disorders.
• Analytical Chemistry: Used as a high-purity standard for chromatography (HPLC, GC) and spectroscopy in quality control laboratories.

Basic Information

Product Name	R-(-)-Mecamylamine Hydrochloride
CAS No.	107596-31-6
Molecular Formula	C11H21N·HCl
Molecular Weight	203.75 g/mol
Synonyms	(R)-(-)-Mecamylamine HCl; (1R,2S,4R)-N,2,3,3-Tetramethylbicyclo[2.2.1]heptan-2-amine Hydrochloride; (R)-3-Methylaminoisocamphane Hydrochloride; Dexmecamylamine Hydrochloride; R(-)-Mecamylamine HCl; (-)-Mecamylamine Hydrochloride
EINECS	Contact for details

Quality Control

Our R-(-)-Mecamylamine Hydrochloride is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and development. A Certificate of Analysis (COA) detailing identity, purity, and chiral excess is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.