Description

S-(+)-Mecamylamine Hydrochloride is the pharmacologically active enantiomer of mecamylamine hydrochloride, a non-competitive and non-depolarizing ganglionic blocker. This high-purity chiral compound is essential for advanced pharmaceutical research and development, particularly in the study of nicotinic acetylcholine receptors (nAChRs). It is primarily sought by research institutions and pharmaceutical companies engaged in neuroscience, cardiovascular research, and the development of novel therapeutic agents.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for analytical method development, validation, and quality control in drug manufacturing.
• Neuroscience Research: A critical tool for studying the role of neuronal nicotinic receptors in various neurological pathways and disorders.
• Cardiovascular Research: Employed in preclinical studies to investigate ganglionic blockade and its effects on blood pressure and autonomic function.
• Active Pharmaceutical Ingredient (API) Intermediate: Serves as a key chiral building block in the synthesis of specialized pharmaceutical compounds.
• Biochemical Assay Development: Utilized in high-throughput screening (HTS) and in vitro assays to identify and characterize new drug candidates.

Basic Information

Product Name	S-(+)-Mecamylamine Hydrochloride
CAS No.	107596-30-5
Molecular Formula	C11H21N•HCl
Molecular Weight	203.75 g/mol
Synonyms	(+)-Mecamylamine Hydrochloride; (S)-Mecamylamine Hydrochloride; (1S,2R,4S)-N,2,3,3-Tetramethylbicyclo[2.2.1]heptan-2-amine Hydrochloride; Dexmecamylamine Hydrochloride; S-Mecamylamine HCl; Inversine (enantiomer); 3-Methylaminoisocamphane Hydrochloride (S-form)
EINECS	Contact for details

Quality Control

Our S-(+)-Mecamylamine Hydrochloride is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, confirming identity, purity, and enantiomeric excess.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% (S-Enantiomer)
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.