Description

(+)-1-(9-Fluorenyl)Ethyl Chloroformate is a high-purity chiral derivatization reagent primarily used for the enantiomeric resolution and analysis of chiral compounds. Its value lies in its ability to form stable, UV-detectable diastereomers with amines and amino acids, enabling precise analytical quantification. This product is essential for researchers and quality control laboratories in the pharmaceutical, agrochemical, and fine chemical industries who require accurate stereochemical analysis and purity assessment of chiral intermediates and active pharmaceutical ingredients (APIs).

Application

• Chiral Derivatization for HPLC Analysis: Used to prepare diastereomeric derivatives of chiral amines, amino acids, and alcohols for separation and quantification by reversed-phase HPLC with UV detection.
• Enantiomeric Purity Determination: Critical for assessing the enantiomeric excess (ee) of synthetic chiral compounds during process development and quality control in pharmaceutical manufacturing.
• Amino Acid Analysis: Employed in the pre-column derivatization of amino acids for sensitive analytical methods in biochemical research and protein characterization.
• Pharmaceutical Impurity Profiling: Aids in the identification and quantification of chiral impurities in drug substances and finished dosage forms.
• Metabolite Studies: Facilitates the chiral analysis of metabolites in pharmacokinetic and pharmacodynamic research.
• Quality Assurance of Chiral Catalysts & Ligands: Used to verify the enantiopurity of chiral auxiliaries, catalysts, and ligands used in asymmetric synthesis.

Basic Information

Item	Detail
Product Name	(+)-1-(9-Fluorenyl)Ethyl Chloroformate
CAS No.	107474-79-3
Molecular Formula	C₁₇H₁₅ClO₂
Molecular Weight	286.75 g/mol
Synonyms	(+)-FLEC; (R)-(+)-1-(9-Fluorenyl)ethyl chloroformate; (R)-FLEC; (R)-(+)-1-(9-Fluorenyl)ethyl chlorocarbonate; 1-(9H-Fluoren-9-yl)ethyl chloroformate, (R)-; 9-Fluorenylmethyl chloroformate analog; Chiral derivatizing agent FLEC; (R)-(+)-1-(9-Fluorenyl)ethyl chloroformate
EINECS	Contact for details

Quality Control

Our (+)-1-(9-Fluorenyl)Ethyl Chloroformate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assessment by HPLC, to ensure it meets the high standards required for sensitive analytical applications. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, and enantiomeric excess.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. Due to its hygroscopic and moisture-sensitive nature, the container should be sealed under an inert atmosphere (e.g., nitrogen or argon) after each use and allowed to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.