Description

26-Hydroxycholesterol Disulfate is a sulfated oxysterol derivative of significant interest in biochemical and pharmaceutical research. This compound serves as a crucial analytical standard and research tool for investigating cholesterol metabolism, bile acid synthesis, and the role of sulfated steroids in cellular signaling pathways. It is primarily utilized by research institutions, pharmaceutical R&D departments, and diagnostic manufacturers focused on metabolic disorders, liver function, and novel therapeutic targets.

Application

• Biochemical Research Standard: Used as a high-purity reference standard in LC-MS, GC-MS, and HPLC analyses for quantifying oxysterols and their metabolites in biological samples.
• Metabolic Pathway Studies: Essential for investigating the enzymatic pathways of cholesterol hydroxylation and sulfation, particularly in the context of liver and brain biochemistry.
• Cell Signaling Research: Employed in studies exploring the role of sulfated oxysterols as potential ligands for nuclear receptors (e.g., LXR) and other cellular targets.
• Diagnostic Assay Development: Serves as a critical calibrator and control material in the development of clinical diagnostic kits for rare inborn errors of bile acid synthesis.
• Pharmaceutical R&D: Used in drug discovery programs targeting metabolic diseases, atherosclerosis, and neurodegenerative conditions where oxysterol pathways are implicated.

Basic Information

Product Name	26-Hydroxycholesterol Disulfate
CAS No.	107241-08-7
Molecular Formula	C27H46O8S2
Molecular Weight	562.78 g/mol
Synonyms	26-Hydroxycholesterol 3,26-Disulfate; (3β,25R)-26-Hydroxycholest-5-en-3,26-diol 3,26-Disulfate; 26-Hydroxy-3-sulfoxy-cholest-5-en-26-yl hydrogen sulfate; 26-Hydroxycholesterol Disulfate Potassium Salt (common salt form); 26-HC Disulfate; 26-OH-Cholesterol Disulfate; 5-Cholestene-3β,26-diol 3,26-disulfate
EINECS	Contact for details

Quality Control

Our 26-Hydroxycholesterol Disulfate is manufactured under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the exacting standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability, purity, and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.