Description

Trienomycin E CAS NO 107140-29-4 is a potent ansamycin-class antibiotic and antitumor agent derived from microbial fermentation. This compound is valued for its significant biological activity, particularly as a topoisomerase II inhibitor, making it a critical tool in biochemical research and drug discovery. It is primarily utilized by pharmaceutical R&D laboratories, academic institutions, and biotechnology companies focused on developing novel anticancer therapeutics and studying complex enzymatic pathways.

Application

• Anticancer Research: Serves as a key reference standard and active pharmaceutical ingredient (API) in the study of novel chemotherapeutic agents targeting topoisomerase II.
• Biochemical Pathway Analysis: Used as a specific inhibitor to elucidate the role of topoisomerase II in DNA replication, transcription, and repair mechanisms.
• Microbiology Studies: Employed in research investigating its antibiotic properties against Gram-positive bacteria and other susceptible microorganisms.
• Pharmaceutical Development: Acts as a lead compound or intermediate in the synthesis and development of new ansamycin derivatives with improved efficacy and safety profiles.
• Cell Biology & Apoptosis Research: Utilized to induce and study programmed cell death (apoptosis) in various cancer cell lines.
• Mechanism of Action Studies: Critical for in vitro and in vivo studies to understand the precise interaction between ansamycins and their molecular targets.

Basic Information

Product Name	Trienomycin E
CAS No.	107140-29-4
Molecular Formula	C39H51NO9
Molecular Weight	677.83 g/mol
Synonyms	Trienomycin E; Antibiotic U-62, 184E; U-62184E; Ansamycin antibiotic U-62,184E; 5,17,29-Trihydroxy-3,7,11,15,19,23,27-heptamethyl-2,6,10,14,18,22,26-octaazaoctatriaconta-3,7,11,15,19,23,27-heptaene-1,28-dione
EINECS	Contact for details

Quality Control

Every batch of Trienomycin E is produced and analyzed under strict quality management protocols to ensure identity, purity, and potency for research applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, detailing comprehensive analytical results from techniques including HPLC, NMR, and MS.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 1.0%
Heavy Metals	≤ 20 ppm
Biological Activity	Assayed; COA provided

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.