Description

1,3-Dithiolane-2-Carbonylchloride,4,5-Dimethyl-,[4S-(2Alpha,4Alpha,5Beta)]-(9Ci) is a high-purity, stereochemically defined chiral building block and reagent, identified by CAS number 106760-48-9. This compound is critical for introducing protected dithiolane functionalities in complex organic syntheses, enabling precise control over molecular architecture. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting complex molecular scaffolds.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides where specific stereochemistry is required for biological activity.
• Ligand and Catalyst Preparation: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the development of functional organic materials and polymers with tailored electronic or structural properties.
• Academic and R&D Laboratories: A valuable reagent for methodological studies in organic synthesis and for exploring new chemical transformations.

Basic Information

Product Name	1,3-Dithiolane-2-Carbonylchloride,4,5-Dimethyl-,[4S-(2Alpha,4Alpha,5Beta)]-(9Ci)
CAS No.	106760-48-9
Molecular Formula	C6H9ClOS2
Molecular Weight	196.72 g/mol
Synonyms	(4S,5R)-4,5-Dimethyl-1,3-dithiolane-2-carbonyl chloride; (2R,4S,5R)-4,5-Dimethyl-1,3-dithiolane-2-carbonyl chloride; 4,5-Dimethyl-1,3-dithiolane-2-carbonyl chloride, (4S-trans)-; (4S,5R)-4,5-Dimethyl-[1,3]dithiolane-2-carbonyl chloride; 1,3-Dithiolane-2-carbonyl chloride, 4,5-dimethyl-, (4S-trans)-; Chiral 4,5-dimethyl-1,3-dithiolane-2-carbonyl chloride
EINECS	Contact for details

Quality Control

Our production of this advanced chiral intermediate adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for sensitive synthetic applications. Each lot is characterized by Chiral HPLC to confirm enantiomeric purity, with NMR (1H, 13C) and IR spectroscopy for structural verification. A comprehensive Certificate of Analysis (COA) detailing purity, chiral assay, and impurity profile is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.