Description

1,3-Dithiolane-2-Carbonylchloride,4,5-Dimethyl-,[4R-(2Alpha,4Alpha,5Beta)]-(9Ci) is a high-purity, stereochemically defined chiral building block essential for advanced organic synthesis. Its value lies in its reactive acid chloride group and protected dithiolane moiety, enabling precise construction of complex molecular architectures. This compound is critically needed by pharmaceutical R&D and fine chemical manufacturers for applications in asymmetric synthesis and the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of potential drug candidates, particularly in antiviral and metabolic disease research.
• Asymmetric Catalysis Ligand Precursor: Serves as a starting material for synthesizing sophisticated chiral ligands used in transition metal catalysis.
• Peptidomimetic & Bio-conjugate Chemistry: Used to introduce dithiolane-protected functional groups into peptide analogs and bioconjugation linkers.
• Material Science Research: Employed in the development of novel organic electronic materials and polymers with specific stereochemical properties.
• Agrochemical Synthesis: Intermediate in the research and development of new, stereoselective crop protection agents.
• Academic & Industrial R&D: A valuable tool for methodological studies in organic chemistry and process development.

Basic Information

Product Name	1,3-Dithiolane-2-Carbonylchloride,4,5-Dimethyl-,[4R-(2Alpha,4Alpha,5Beta)]-(9Ci)
CAS No.	106760-47-8
Molecular Formula	C6H9ClOS2
Molecular Weight	196.72 g/mol
Synonyms	(4R,5R)-4,5-Dimethyl-1,3-dithiolane-2-carbonyl chloride; (2R,4R,5R)-4,5-Dimethyl-1,3-dithiolane-2-carbonyl chloride; (R,R)-4,5-Dimethyl-1,3-dithiolane-2-carbonyl chloride; Dithiolane carbonyl chloride, dimethyl-; Chiral dithiolane acid chloride; 2-Carbonylchloride-4,5-dimethyl-1,3-dithiolane
EINECS	Contact for details

Quality Control

Our 1,3-Dithiolane-2-Carbonylchloride,4,5-Dimethyl-,[4R-(2Alpha,4Alpha,5Beta)]-(9Ci) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC and structural confirmation by NMR and IR spectroscopy, to ensure high chemical and enantiomeric purity. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting cGMP-compliant development workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.