Description

Adapalene is a synthetic third-generation retinoid compound, widely recognized for its potent pharmacological activity. This active pharmaceutical ingredient (API) is a cornerstone in the development of topical dermatological treatments, offering a favorable balance of efficacy and tolerability. It is primarily utilized by pharmaceutical manufacturers and R&D institutions in the global healthcare sector for formulating acne vulgaris medications.

Application

• Topical Acne Treatments: The primary and most significant application is as the active ingredient in prescription and over-the-counter gels, creams, and solutions for the treatment of mild to moderate acne vulgaris.
• Dermatological Formulations: Used in combination therapies and specialized formulations targeting inflammatory skin conditions, leveraging its comedolytic and anti-inflammatory properties.
• Pharmaceutical Intermediates: Serves as a key synthetic intermediate in the production of more complex retinoid-based drug candidates under development.
• Research & Development: Employed in preclinical and clinical studies to investigate mechanisms of action, new therapeutic indications, and novel delivery systems for retinoids.
• Cosmeceutical Actives: Incorporated into advanced skincare products aimed at addressing photoaging, texture improvement, and other signs of skin damage, subject to regional regulatory approvals.

Basic Information

Product Name	Adapalene
CAS No.	106685-40-9
Molecular Formula	C28H28O3
Molecular Weight	412.52 g/mol
Synonyms	CD 271; Adapalene; 6-[3-(1-Adamantyl)-4-methoxyphenyl]-2-naphthoic Acid; Differin (Brand Name); 6-[3-(1-Adamantanyl)-4-methoxyphenyl]naphthalene-2-carboxylic Acid; ADA; GWP-94-B
EINECS	Contact for details

Quality Control

Our Adapalene is manufactured under strict quality management systems, targeting specifications suitable for pharmaceutical applications. We ensure rigorous testing for identity, purity, and impurity profiles, with processes designed to meet ICH Q7 guidelines. A comprehensive Certificate of Analysis (COA) documenting assay, related substances, residual solvents, and other critical parameters is provided with each batch to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a dry environment and opened under conditions of minimal humidity exposure.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Individual impurity: NMT 0.5% Total impurities: NMT 2.0%
Water (KF)	NMT 1.0%
Residue on Ignition	NMT 0.1%
Heavy Metals	NMT 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.