Description

2'-Deoxyisoguanosine is a synthetic nucleoside analog of significant interest in advanced biochemical and pharmaceutical research. This compound serves as a critical building block and research tool in the development of novel therapeutic agents and diagnostic probes. It is primarily utilized by research institutions and pharmaceutical companies engaged in nucleic acid chemistry, antiviral drug discovery, and oligonucleotide synthesis. The high-purity material is essential for studies involving DNA modification, enzyme-substrate interactions, and the exploration of novel genetic mechanisms.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel nucleoside-based antiviral and anticancer drug candidates.
• Biochemical Research: Essential tool for studying DNA repair mechanisms, polymerase activity, and nucleic acid metabolism.
• Oligonucleotide Synthesis: Used as a modified nucleoside phosphoramidite in the solid-phase synthesis of specialized DNA strands for diagnostic and therapeutic applications.
• Antiviral Studies: Investigated for its potential to inhibit viral replication by acting as a chain terminator or mutagen in viral RNA/DNA.
• Enzymology Studies: Serves as a substrate or inhibitor for enzymes like nucleoside kinases and polymerases to understand enzyme kinetics and specificity.
• Probe Development: Utilized in the creation of labeled nucleotides for fluorescence in situ hybridization (FISH) and other detection methodologies.

Basic Information

Product Name	2'-Deoxyisoguanosine
CAS No.	106449-56-3
Molecular Formula	C10H13N5O4
Molecular Weight	267.24 g/mol
Synonyms	2'-Deoxy-iso-guanosine; 9-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,9-dihydro-6H-purin-6-one; Iso-dG; 2'-Deoxy-iso-guanine riboside; 2'-Deoxyisoguanine nucleoside; 2'-Deoxy-iso-G; 2'-Deoxy-iso-guanosine (iso-dG)
EINECS	Contact for details

Quality Control

Our 2'-Deoxyisoguanosine is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable, and our quality systems are designed to meet the stringent requirements of the pharmaceutical and biotechnology industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Solubility	Soluble in DMSO, slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.