Description

2-Bromo-2-Methylbutanoyl Bromide is a versatile and highly reactive acyl bromide intermediate, essential for introducing the 2-bromo-2-methylbutyryl functional group. Its primary value lies in enabling precise synthetic modifications in advanced organic chemistry, particularly in the construction of complex molecules. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for applications such as active pharmaceutical ingredient (API) synthesis and the development of novel crop protection agents.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), especially for compounds requiring a branched halogenated acyl moiety.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the 2-bromo-2-methylbutyryl group impributes specific biological activity.
• Polymer Chemistry: Serves as a functional monomer or chain-transfer agent in the synthesis of specialty polymers with tailored properties.
• Organic Synthesis Reagent: Employed in academic and industrial laboratories for acylation reactions, Friedel-Crafts alkylations, and the preparation of other functionalized intermediates.
• Material Science Research: Utilized in the development of novel organic materials, including liquid crystals and organic semiconductors.
• Peptide Modification: Can be used for the selective modification of peptides and proteins to study structure-activity relationships.

Basic Information

Product Name	2-Bromo-2-Methylbutanoyl Bromide
CAS No.	106265-07-0
Molecular Formula	C5H8Br2O
Molecular Weight	243.93 g/mol
Synonyms	2-Bromo-2-methylbutyryl bromide; α-Bromoisovaleryl bromide; 2-Methyl-2-bromobutanoyl bromide; 2-Bromo-2-methylbutanoic acid bromide; Butanoyl bromide, 2-bromo-2-methyl-; Bromoisovaleryl bromide; 2-Bromoisovaleric acid bromide
EINECS	Contact for details

Quality Control

Every batch of 2-Bromo-2-Methylbutanoyl Bromide is manufactured and tested under strict quality management systems to ensure consistency and reliability for your critical processes. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as purity (by GC/HPLC), identity (by IR/NMR), and impurity profiles. Our quality commitment aligns with cGMP principles where applicable, supporting its use in regulated synthesis pathways.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature and reactivity as a strong acid/organic solvent, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, open flames, and incompatible materials such as bases, alcohols, and amines.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 97.0%
Purity (HPLC)	≥ 96.0%
Water Content (KF)	≤ 0.5%
Density (at 20°C)	~1.7 g/mL
Refractive Index (n20D)	~1.51

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.