Description

5'-Methylthio-5'-Deoxy-9-Deazaadenosine is a chemically modified nucleoside analog, a key intermediate in the synthesis of novel pharmaceutical compounds. This compound matters for its role in medicinal chemistry research, particularly in the development of enzyme inhibitors and antiviral or anticancer agents targeting nucleotide metabolism. It is primarily needed by pharmaceutical R&D laboratories, biotechnology companies, and academic research institutions focused on drug discovery and biochemical pathway studies.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel nucleoside-based therapeutics.
• Enzyme Inhibition Studies: Used in biochemical research to investigate and modulate the activity of methylthioadenosine phosphorylase (MTAP) and related enzymes.
• Antiviral/Anticancer Agent Research: Serves as a precursor in the development of potential prodrugs targeting viral replication or specific cancer cell pathways.
• Biochemical Probe: Employed as a tool compound to study purine salvage pathways and cellular signaling mechanisms.
• Reference Standard: Used as a high-purity analytical standard in quality control and method development for pharmaceutical analysis.

Basic Information

Product Name	5'-Methylthio-5'-Deoxy-9-Deazaadenosine
CAS No.	106175-18-2
Molecular Formula	C12H15N5O3S
Molecular Weight	309.35 g/mol
Synonyms	9-Deaza-5'-methylthio-5'-deoxyadenosine; 5'-Deoxy-5'-(methylthio)-9-deazaadenosine; MTDDA; 5'-S-Methyl-5'-thio-9-deazaadenosine; 4-Amino-7-[(2R,3R,4S,5R)-3,4-dihydroxy-5-[(methylthio)methyl]oxolan-2-yl]-7H-pyrrolo[2,3-d]pyrimidine
EINECS	Contact for details

Quality Control

Our 5'-Methylthio-5'-Deoxy-9-Deazaadenosine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by spectroscopic methods (NMR, MS). We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters to ensure compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a desiccated environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.