Description

1H-Pyrrole-2-Carbonyl Chloride, 5-Chloro-1-Methyl- (9Ci) is a specialized heterocyclic building block and reactive intermediate of significant importance in advanced organic synthesis. Its value lies in its dual functionality, serving as a key precursor for constructing complex molecular architectures, particularly in the pharmaceutical and agrochemical sectors. This compound is essential for research chemists and process development scientists working on novel active ingredients, where its unique pyrrole core enables the introduction of critical amide and ester linkages.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing functionalized pyrrole or indole motifs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides that require specific heterocyclic scaffolds.
• Material Science Research: Serves as a monomer or precursor for developing functional polymers, organic semiconductors, and conductive materials.
• Dye and Pigment Manufacturing: Employed in the synthesis of complex organic dyes and pigments where the pyrrole structure contributes to color properties.
• Chemical Biology & Proteomics: Acts as a reactive handle for labeling biomolecules or synthesizing enzyme inhibitors and probes for biological studies.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences industry.

Basic Information

Product Name	1H-Pyrrole-2-Carbonyl Chloride, 5-Chloro-1-Methyl- (9Ci)
CAS No.	106116-34-1
Molecular Formula	C6H5Cl2NO
Molecular Weight	178.02 g/mol
Synonyms	5-Chloro-1-methyl-1H-pyrrole-2-carbonyl chloride; 5-Chloro-1-methylpyrrole-2-carboxylic acid chloride; 1-Methyl-5-chloropyrrole-2-carbonyl chloride; 2-Carbonyl chloride-5-chloro-1-methylpyrrole; 5-Chloro-1-methyl-2-pyrrolecarbonyl chloride
EINECS	Contact for details

Quality Control

Our production of 1H-Pyrrole-2-Carbonyl Chloride, 5-Chloro-1-Methyl- (9Ci) adheres to stringent quality management protocols to ensure batch-to-batch consistency and reliability for your critical synthesis workflows. Each lot undergoes comprehensive analytical characterization, including HPLC for purity and identity confirmation via NMR and IR spectroscopy. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We operate under a quality system designed to meet the exacting standards of pharmaceutical and fine chemical industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from strong acids and organic solvents.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline solid or powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.