Description

3'-Azido-3'-Deoxythymidine 5'-Diphosphate is a chemically modified nucleotide analog, a key intermediate in the synthesis of nucleoside-based prodrugs and research compounds. Its value lies in its role as a specialized building block for developing antiviral agents and biochemical probes, particularly in the study of reverse transcriptase inhibition. This high-purity biochemical is essential for pharmaceutical R&D laboratories, biotechnology companies, and academic institutions focused on virology, medicinal chemistry, and nucleotide metabolism research.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of novel nucleoside reverse transcriptase inhibitors (NRTIs) and other antiviral prodrugs.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies, particularly those involving DNA polymerases and reverse transcriptase enzymes.
• Probe Development: Serves as a precursor for creating labeled or tagged nucleotides for diagnostic assays and molecular biology research.
• Medicinal Chemistry: A key starting material in structure-activity relationship (SAR) studies to develop new therapeutic agents targeting viral replication.
• Antiviral Agent Synthesis: Directly utilized in the research and development pathways for compounds analogous to Azidothymidine (AZT).

Basic Information

Product Name	3'-Azido-3'-Deoxythymidine 5'-Diphosphate
CAS No.	106060-89-3
Molecular Formula	C10H15N5O12P2
Molecular Weight	459.20 g/mol
Synonyms	AZT Diphosphate; 3'-Azido-3'-deoxythymidine 5'-diphosphate; 3'-Azido-2',3'-dideoxythymidine 5'-diphosphate; AZT-DP; 5'-ADP-3'-azido-3'-deoxythymidine; Thymidine, 3'-azido-3'-deoxy-, 5'-(trihydrogen diphosphate); 3'-N3-TDP
EINECS	Contact for details

Quality Control

We supply 3'-Azido-3'-Deoxythymidine 5'-Diphosphate with a focus on high-purity grades suitable for research and development. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request. For specific pharmacopeial standards (e.g., USP, EP) or custom purity requirements, please contact our technical team.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This compound is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, consider desiccant and under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Solvent Residues (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.