Description

3-[4-(Trifluoromethyl)Phenyl]-2-Propenoylhloride is a versatile and reactive chemical intermediate featuring a trifluoromethylphenyl group attached to an acryloyl chloride moiety. This compound is valued for its ability to introduce both the lipophilic, electron-withdrawing trifluoromethylphenyl group and a highly reactive acid chloride functional group into target molecules. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, particularly where the modulation of pharmacokinetic properties is desired.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially protease inhibitors and kinase inhibitors where the trifluoromethyl group enhances metabolic stability and membrane permeability.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and insecticides, leveraging the bioactivity imparted by the trifluoromethylphenyl moiety.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the development of specialty polymers and advanced organic materials with specific optical or electronic properties.
• Ligand and Catalyst Development: Employed in organic synthesis to construct complex ligands for catalysis or as a scaffold in medicinal chemistry for structure-activity relationship (SAR) studies.
• Fluorinated Compound Library Synthesis: A critical reagent in combinatorial and parallel synthesis for generating diverse libraries of fluorinated compounds for high-throughput screening.

Basic Information

Product Name	3-[4-(Trifluoromethyl)Phenyl]-2-Propenoylhloride
CAS No.	105919-36-6
Molecular Formula	C10H6ClF3O
Molecular Weight	234.60 g/mol
Synonyms	4-(Trifluoromethyl)cinnamoyl chloride; (E)-3-[4-(Trifluoromethyl)phenyl]prop-2-enoyl chloride; 3-(4-Trifluoromethylphenyl)acryloyl chloride; 2-Propenoyl chloride, 3-[4-(trifluoromethyl)phenyl]-; α,β-Unsaturated acid chloride of 4-(trifluoromethyl)cinnamic acid; (E)-4-Trifluoromethylcinnamoyl chloride; p-Trifluoromethylcinnamoyl chloride
EINECS	Contact for details

Quality Control

Our production of 3-[4-(Trifluoromethyl)Phenyl]-2-Propenoylhloride adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via FT-IR and NMR spectroscopy, to ensure consistency and reliability. A Certificate of Analysis (COA) detailing specific results for purity, appearance, and relevant impurities is provided with each shipment, supporting your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis. Keep away from strong bases, oxidizers, and sources of ignition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.