Description

N(6)-2-(4-Azido-3-Iodophenyl)Ethyladenosine is a specialized, bifunctional chemical probe designed for photoaffinity labeling and cross-linking studies in biochemical research. This compound matters because it combines the photoreactive azido group with the adenosine moiety, enabling the covalent tagging and identification of adenosine-binding proteins and receptors. It is primarily needed by pharmaceutical R&D teams, academic biochemists, and contract research organizations (CROs) engaged in target identification, ligand-receptor interaction mapping, and proteomics.

Application

• Photoaffinity Labeling Probe: Used to covalently tag and identify adenosine A1, A2A, and A3 receptor subtypes upon UV irradiation for target deconvolution.
• Biochemical Cross-linking Agent: Facilitates the study of protein-protein and protein-ligand interactions in complex biological samples.
• Proteomics Research: Serves as a critical tool for mapping adenosine-binding sites and understanding signaling pathways in cell lysates and membranes.
• Drug Discovery Target Validation: Employed in early-stage pharmaceutical research to validate and characterize novel adenosine receptor targets.
• Chemical Biology Tool Compound: Utilized to create activity-based probes for functional studies of purinergic signaling.
• Radioligand Displacement Studies: Acts as a high-affinity, non-radioactive competitor in binding assays to determine receptor affinity and specificity.

Basic Information

Product Name	N(6)-2-(4-Azido-3-Iodophenyl)Ethyladenosine
CAS No.	105811-49-2
Molecular Formula	C18H18IN9O4
Molecular Weight	575.30 g/mol
Synonyms	2-[4-Azido-3-iodophenyl]ethyladenosine; N6-[2-(4-Azido-3-iodophenyl)ethyl]adenosine; 2-(4-Azido-3-iodobenzyl)adenosine; AIA; Adenosine, N6-[2-(4-azido-3-iodophenyl)ethyl]-; Photoaffinity Label for Adenosine Receptors; Bifunctional Adenosine Probe
EINECS	Contact for details

Quality Control

Our N(6)-2-(4-Azido-3-Iodophenyl)Ethyladenosine is manufactured under strict quality protocols to ensure batch-to-batch consistency and high purity for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and stability data. We adhere to ISO 9001 quality management standards, and our analytical methods are validated to meet the rigorous demands of pharmaceutical and academic research.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This compound is hygroscopic (moisture-sensitive) and light-sensitive. For long-term stability, store under an inert atmosphere (argon or nitrogen) and avoid repeated freeze-thaw cycles. Keep away from strong acids and organic solvents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.