Description

Ethyl Chloroformate, [Carboxyl-14C] is a carbon-14 radiolabeled derivative of ethyl chloroformate, a versatile reagent used in organic synthesis. This isotopically labeled compound is essential for conducting detailed metabolic, pharmacokinetic, and environmental fate studies, providing critical traceability and analytical sensitivity. It is primarily required by research scientists and process chemists in the pharmaceutical, agrochemical, and life science research sectors for advanced analytical and synthetic applications.

Application

• Tracer Studies in Metabolism & Pharmacokinetics (PK/ADME): Used as a radiolabeled precursor to synthesize target molecules for tracking absorption, distribution, metabolism, and excretion in biological systems.
• Mechanistic Organic Chemistry Research: Serves as a tagged reagent for studying reaction mechanisms and pathways, particularly in carboxylation and carbonate formation reactions.
• Environmental Fate and Degradation Studies: Employed to label compounds for investigating degradation pathways, persistence, and metabolite identification in environmental samples.
• Synthesis of Radiolabeled Intermediates: A key building block for the preparation of carbon-14 labeled pharmaceuticals, agrochemicals, and other fine chemicals.
• Analytical Method Development: Used as a standard or derivatization agent in the development of sensitive LC-MS or radio-HPLC analytical methods.

Basic Information

Product Name	Ethyl Chloroformate, [Carboxyl-14C]
CAS No.	105802-19-5
Molecular Formula	C14ClHO2 / C14O(O)CH2CH3
Molecular Weight	~108.49 g/mol (for 12C form; exact mass varies with 14C position)
Synonyms	Carbon-14 Labeled Ethyl Chloroformate; [Carbonyl-14C]Ethyl Chloroformate; Ethyl Carbonochloridate-14C; Chloroformic Acid Ethyl Ester-14C; Ethoxycarbonyl Chloride-14C; Ethyl Chlorocarbonate-14C; [14C]Ethyl Chloroformate
EINECS	Contact for details

Quality Control

Every batch of our radiolabeled Ethyl Chloroformate, [Carboxyl-14C] is produced and analyzed under strict quality systems to ensure high chemical and radiochemical purity, specific activity, and stability. Comprehensive testing includes identity confirmation, assay, and radiochemical purity analysis by techniques such as HPLC with radiometric detection. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical parameters. Our quality commitment aligns with the stringent requirements for research chemicals in regulated discovery and development environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) in a sealed vial to maintain stability and prevent hydrolysis. For long-term storage, keep at 2-8°C. Handle and store in accordance with all local, national, and international regulations for radioactive materials.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR / NMR)	Conforms to structure
Chemical Purity (HPLC)	≥ 98.0%
Radiochemical Purity (Radio-HPLC)	≥ 97.0%
Specific Activity	Customizable (mCi/mmol)
Solvent (if supplied as solution)	Specified on COA (e.g., Toluene, Acetonitrile)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.