Description

5-Iodo-2',3'-Dideoxyuridine is a halogenated nucleoside analog, a key intermediate in antiviral and anticancer research. This compound matters for its role as a precursor in the synthesis of more complex therapeutic agents, particularly those targeting viral polymerases. Pharmaceutical researchers and fine chemical manufacturers need it for developing novel antiviral drugs and conducting biochemical studies on nucleoside metabolism.

Application

• Antiviral Drug Research: Serves as a critical building block in the synthesis of nucleoside reverse transcriptase inhibitors (NRTIs) for HIV and other viral targets.
• Oncology Research: Used as a precursor in developing prodrugs and chemotherapeutic agents that interfere with DNA synthesis in cancer cells.
• Biochemical Probe: Employed in enzymatic studies to investigate the mechanism of action of viral polymerases and cellular DNA/RNA polymerases.
• Radiopharmaceuticals: The iodine atom provides a handle for radiolabeling (e.g., with I-125 or I-131) for diagnostic imaging or targeted radiotherapy research.
• Academic & Contract Research: Essential for universities and CROs conducting fundamental research in medicinal chemistry and virology.
• Fine Chemical Synthesis: A versatile intermediate for custom synthesis and the production of specialized nucleotide libraries for high-throughput screening.

Basic Information

Product Name	5-Iodo-2',3'-Dideoxyuridine
CAS No.	105784-83-6
Molecular Formula	C9H11IN2O5
Molecular Weight	354.10 g/mol
Synonyms	5-Iodo-2',3'-dideoxyuridine; 5-Iodo-ddU; 1-[(2R,5S)-5-(Hydroxymethyl)oxolan-2-yl]-5-iodopyrimidine-2,4-dione; 5-Iodo-1-[(2R,5S)-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidine-2,4(1H,3H)-dione; IDU-dd; 2',3'-Dideoxy-5-iodouridine; 5-Iodo-2',3'-dideoxyuridine (IDUdd); 5-I-2',3'-ddU
EINECS	Contact for details

Quality Control

Our 5-Iodo-2',3'-Dideoxyuridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals to ensure it meets the high standards required for research and pharmaceutical development. Certificates of Analysis (COA) with complete analytical data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept in a desiccated environment to prevent moisture absorption, which can affect stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.