Description

3'-Azido-2',3'-Dideoxy-5-Bromouridine is a chemically modified nucleoside analog, a key building block in medicinal chemistry and life science research. Its unique structure, incorporating both an azido group and a bromine atom, makes it a versatile intermediate for the synthesis of novel antiviral and anticancer agents. This compound is primarily utilized by pharmaceutical R&D departments, biotechnology companies, and academic research institutions focused on nucleoside-based drug discovery and biochemical probe development.

Application

• Antiviral Drug Discovery: Serves as a critical synthetic precursor for the development of nucleoside reverse transcriptase inhibitors (NRTIs) and other antiviral compounds.
• Oncology Research: Used in the synthesis of potential chemotherapeutic agents that target DNA replication in cancer cells.
• Biochemical Probe Synthesis: The azido group enables "click chemistry" applications, allowing for the labeling and tracking of biomolecules in cellular studies.
• Medicinal Chemistry Intermediate: A foundational scaffold for creating libraries of modified nucleosides to explore structure-activity relationships (SAR).
• Academic & Institutional Research: Employed in studies investigating nucleotide metabolism, enzyme mechanisms, and the biochemical basis of disease.

Basic Information

Product Name	3'-Azido-2',3'-Dideoxy-5-Bromouridine
CAS No.	105784-82-5
Molecular Formula	C9H10BrN5O5
Molecular Weight	348.11 g/mol
Synonyms	5-Bromo-3'-azido-2',3'-dideoxyuridine; 5-Br-AzddU; 3'-Azido-5-bromo-2',3'-dideoxyuridine; 5-Bromo-3'-azido-3'-deoxythymidine analog; AZT-5-Br analog; 1-((2R,3S,5R)-3-Azido-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-bromopyrimidine-2,4(1H,3H)-dione
EINECS	Contact for details

Quality Control

We supply 3'-Azido-2',3'-Dideoxy-5-Bromouridine in high-purity grades suitable for research and development. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request. We adhere to strict quality management protocols to ensure batch-to-batch consistency and reliability for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants and an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.