Description

(+)-1-(9-Fluorenyl)Ethyl Chloroformate is a specialized chiral derivatizing agent widely used in analytical chemistry for the resolution and analysis of enantiomers. Its core value lies in its ability to react with amines and amino acids to form stable, UV-absorbing diastereomers, enabling precise chromatographic separation. This high-purity reagent is essential for researchers and quality control laboratories in the pharmaceutical, biotechnology, and fine chemical sectors who require accurate stereochemical analysis and chiral purity determination.

Application

• Chiral Derivatization for HPLC Analysis: Primary use in pre-column derivatization of chiral amines, amino acids, and pharmaceuticals to facilitate their separation and quantification via reversed-phase or normal-phase HPLC.
• Enantiomeric Purity Testing: Critical for determining the enantiomeric excess (ee) of synthetic intermediates and active pharmaceutical ingredients (APIs) during process development and quality assurance.
• Amino Acid Analysis: Employed in the sensitive detection and resolution of D- and L-amino acids in protein hydrolysates, peptide synthesis, and metabolic studies.
• Pharmaceutical Research: Used in the development and validation of analytical methods for chiral drugs, supporting regulatory filings and stability testing.
• Biomarker Discovery: Aids in the stereospecific analysis of chiral metabolites in biofluids for clinical research and diagnostic applications.
• Fine Chemical Synthesis: Serves as a chiral auxiliary or protecting group in asymmetric synthesis routes for complex organic molecules.

Basic Information

Product Name	(+)-1-(9-Fluorenyl)Ethyl Chloroformate
CAS No.	105764-39-4
Molecular Formula	C18H15ClO2
Molecular Weight	298.76 g/mol
Synonyms	(+)-FLEC; (R)-(+)-1-(9-Fluorenyl)ethyl chloroformate; (R)-FLEC; (+)-1-(9-Fluorenyl)ethyl chlorocarbonate; (R)-(+)-1-(9-Fluorenyl)ethyl chlorocarbonate; 1-(9H-Fluoren-9-yl)ethyl chloroformate, (R)-; 9-Fluorenylmethyl chloroformate, (R)-(+)-1-(9-Fluorenyl)ethyl analog; Chiral derivatizing agent FLEC
EINECS	Contact for details

Quality Control

Our (+)-1-(9-Fluorenyl)Ethyl Chloroformate is manufactured under strict quality control protocols to ensure high chiral purity and batch-to-batch consistency, suitable for sensitive analytical applications. Each lot is characterized by HPLC, NMR, and optical rotation analysis to confirm identity, chemical purity, and enantiomeric excess. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific customer or pharmacopeial requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive); ensure containers are sealed under an inert atmosphere after opening to maintain stability and prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Enantiomeric Excess)	≥ 99.0% ee
Specific Optical Rotation [α]	+55.0° to +65.0° (c=1 in THF)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.