Description

Boc-o-Diphenylphospho-L-Serine CAS NO 105751-07-3 is a high-purity, protected amino acid derivative essential for advanced peptide synthesis and medicinal chemistry research. This compound serves as a critical building block for introducing phosphoserine mimetics, enabling the study of phosphorylation-dependent biological processes. It is primarily utilized by pharmaceutical R&D teams, biotech companies, and academic laboratories focused on developing novel therapeutics, particularly in the areas of oncology and signal transduction.

Application

• Pharmaceutical Intermediate: A key precursor in the solid-phase and solution-phase synthesis of complex peptides and peptidomimetics targeting protein-protein interactions.
• Phosphopeptide Synthesis: Specifically used for the incorporation of phosphoserine analogs into peptide chains to mimic post-translational modifications for biological activity studies.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to develop kinase inhibitors and modulators of phospho-dependent signaling pathways.
• Bioconjugation & Probe Development: Useful for creating labeled peptides or affinity probes for proteomics and biochemical assay development.
• Chemical Biology Tool: Facilitates the study of phosphorylation events in vitro, aiding in the understanding of disease mechanisms.

Basic Information

Product Name	Boc-o-Diphenylphospho-L-Serine
CAS No.	105751-07-3
Molecular Formula	C20H24NO7P
Molecular Weight	421.38 g/mol
Synonyms	N-(tert-Butoxycarbonyl)-O-(diphenylphospho)-L-serine; Boc-Ser(PO(Ph)2)-OH; (2S)-2-[(tert-Butoxycarbonyl)amino]-3-[diphenoxyphosphoryl]oxy]propanoic acid; Boc-L-Serine O-diphenyl phosphate; tert-Butyloxycarbonyl-O-diphenylphosphono-L-serine; L-Serine, N-[(1,1-dimethylethoxy)carbonyl]-, O-(diphenyl phosphate); 105751-07-3; Boc-Ser(PO3Ph2)-OH
EINECS	Contact for details

Quality Control

Our Boc-o-Diphenylphospho-L-Serine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing including HPLC, NMR, and mass spectrometry for identity and purity verification. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.