Description

5-Bromo-2',3',5'-Tri-o-Acetyluridine is a key protected nucleoside intermediate used in the synthesis of modified oligonucleotides and other bioactive molecules. Its primary value lies in providing a reactive bromo site for further functionalization while the acetyl groups protect the ribose hydroxyls, enabling selective and efficient chemical transformations. This compound is essential for researchers and manufacturers in pharmaceutical development, antisense therapy, and diagnostic probe synthesis, where precise molecular construction is critical.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel nucleoside-based antiviral and anticancer agents.
• Oligonucleotide Synthesis: Used in the preparation of modified RNA and DNA strands for antisense and siRNA therapeutic applications.
• Bioconjugation & Probe Development: Serves as a starting material for creating labeled nucleotides used in diagnostic assays and imaging probes.
• Medicinal Chemistry Research: Enables structure-activity relationship (SAR) studies by allowing modifications at the 5-position of the uracil ring.
• Chemical Biology Tools: Facilitates the development of cross-linking agents and affinity tags for studying nucleic acid-protein interactions.
• Academic & Industrial R&D: Supports fundamental research in nucleic acid chemistry and the development of new therapeutic modalities.

Basic Information

Item	Detail
Product Name	5-Bromo-2',3',5'-Tri-o-Acetyluridine
CAS No.	105659-32-3
Molecular Formula	C15H17BrN2O9
Molecular Weight	449.21 g/mol
Synonyms	5-Bromo-2',3',5'-tri-O-acetyluridine; 1-[(2R,3R,4R,5R)-3,4-Diacetyloxy-5-(acetyloxymethyl)oxolan-2-yl]-5-bromopyrimidine-2,4-dione; 2',3',5'-Tri-O-acetyl-5-bromouridine; 5-Br-Ac3Urd; 5-Bromouridine 2',3',5'-triacetate; Uridine, 5-bromo-2',3',5'-triacetate
EINECS	Contact for details

Quality Control

Our 5-Bromo-2',3',5'-Tri-o-Acetyluridine is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and mass spectrometry, to ensure it meets the high standards required for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines
Specific Rotation	Contact for details
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.