Description

Benzeneacetyl Chloride, 4-Fluoro-α-Oxo- (9Ci) CAS NO 105457-90-7 is a specialized fluorinated aromatic acid chloride derivative, serving as a high-value synthetic intermediate in advanced organic synthesis. Its core value lies in introducing both a reactive acyl chloride group and a fluorine substituent onto a benzene ring, enabling precise molecular construction for complex target molecules. This compound is essential for research chemists and process development scientists in the pharmaceutical and agrochemical industries who require building blocks for creating novel active ingredients with enhanced properties.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of fluorinated drug candidates, particularly in protease inhibitors, kinase inhibitors, and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, where the fluorine atom can improve metabolic stability and bioactivity.
• Material Science Precursor: Employed in the creation of specialty polymers and advanced organic materials that require fluorinated aromatic components for specific thermal or chemical resistance.
• Chemical Research & Development: A versatile reagent for academic and industrial R&D labs exploring new fluorination methodologies, peptide mimetics, and molecular probes.
• Ligand and Catalyst Development: Serves as a starting material for synthesizing complex fluorinated ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).

Basic Information

Product Name	Benzeneacetyl Chloride, 4-Fluoro-α-Oxo- (9Ci)
CAS No.	105457-90-7
Molecular Formula	C8H4ClFO2
Molecular Weight	186.57 g/mol
Synonyms	4-Fluorobenzoyl Chloride, 2-Oxo-; 2-(4-Fluorophenyl)-2-oxoacetyl Chloride; 4-Fluoro-α-oxobenzeneacetyl Chloride; 4-Fluorophenacyl Chloride; 4-Fluorophenglyoxyl Chloride; 4-Fluorobenzoylformyl Chloride; α-Oxo-4-fluorobenzeneacetyl Chloride
EINECS	Contact for details

Quality Control

Our Benzeneacetyl Chloride, 4-Fluoro-α-Oxo- (9Ci) is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and scale-up applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality management system is designed to meet the stringent requirements of cGMP and ISO standards where applicable, supporting our commitment to supply reliability and technical excellence for our global B2B partners.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis. Keep away from strong bases, oxidizing agents, and sources of ignition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.