Description

2-Pyrrolidinecarbonylchloride,1-Acetyl-5-Oxo-,(S)-(9Ci) is a high-purity chiral building block and key synthetic intermediate. This compound matters for its role in constructing complex molecular architectures, particularly in the synthesis of enantiomerically pure pharmaceuticals and bioactive compounds. It is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries who require reliable, high-quality intermediates for advanced synthesis.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the research and development of novel active pharmaceutical ingredients (APIs), particularly in classes like protease inhibitors and other enzyme-targeted therapies.
• Asymmetric Synthesis: Used as a key reagent in stereoselective reactions to introduce the (S)-configured pyrrolidine moiety, a common structural motif in medicinal chemistry.
• Peptidomimetic Research: Serves as a building block for creating peptidomimetics and constrained peptides, which are important in drug discovery for modulating protein-protein interactions.
• Agrochemical Synthesis: Employed in the development of advanced, enantiomerically pure agrochemicals where specific stereochemistry is crucial for biological activity.
• Catalyst Ligand Precursor: Can be utilized in the synthesis of specialized ligands for asymmetric catalysis.
• Academic & Industrial R&D: A valuable compound for methodological development in organic synthesis and for exploring new chemical spaces in discovery chemistry.

Basic Information

Product Name	2-Pyrrolidinecarbonylchloride,1-Acetyl-5-Oxo-,(S)-(9Ci)
CAS No.	105425-26-1
Molecular Formula	C7H8ClNO3
Molecular Weight	189.60 g/mol
Synonyms	(S)-1-Acetyl-5-oxopyrrolidine-2-carbonyl chloride; (S)-N-Acetyl-5-oxoproline chloride; (S)-1-Acetyl-5-oxo-L-prolyl chloride; 1-Acetyl-5-oxo-L-proline chloride; L-1-Acetyl-5-oxoproline acid chloride; (S)-1-Acetyl-5-oxoproline acid chloride; 5-Oxo-1-acetyl-L-proline chloride; (S)-5-Oxo-1-acetylproline chloride
EINECS	Contact for details

Quality Control

Our 2-Pyrrolidinecarbonylchloride,1-Acetyl-5-Oxo-,(S)-(9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.