Description

2-Pyrrolidinecarbonyl Chloride, 1-(2-Methoxyethyl)-5-Oxo-, (S)- (9Ci) is a high-value chiral building block and activated intermediate in advanced organic synthesis. Its core value proposition lies in enabling the efficient, stereoselective construction of complex molecular architectures, which is critical for developing active pharmaceutical ingredients (APIs) and fine chemicals. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries who require reliable, high-purity intermediates for complex synthesis.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, particularly in the development of protease inhibitors, neurological agents, and other biologically active molecules.
• Peptide Mimetic Synthesis: Used to introduce constrained proline-like structures or lactam bridges into peptide chains to enhance metabolic stability and receptor binding affinity.
• Agrochemical Research: Serves as a building block for creating chiral active ingredients in advanced herbicides, fungicides, and insecticides.
• Asymmetric Catalysis Ligand Precursor: Acts as a starting material for the synthesis of novel chiral ligands used in asymmetric hydrogenation and other catalytic transformations.
• Material Science: Potential use in the synthesis of specialized polymers and functional materials requiring specific stereochemistry.
• Custom Synthesis & Contract Manufacturing: A critical intermediate for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences market.

Basic Information

Product Name	2-Pyrrolidinecarbonyl Chloride, 1-(2-Methoxyethyl)-5-Oxo-, (S)- (9Ci)
CAS No.	105425-16-9
Molecular Formula	C8H12ClNO3
Molecular Weight	205.64 g/mol
Synonyms	(S)-1-(2-Methoxyethyl)-5-oxopyrrolidine-2-carbonyl chloride; (S)-1-(2-Methoxyethyl)-2-pyrrolidinone-5-carbonyl chloride; 1-(2-Methoxyethyl)-5-oxo-(S)-proline chloride; L-Proline, 1-(2-methoxyethyl)-5-oxo-, chloride (9CI); 5-Oxo-1-(2-methoxyethyl)-L-prolyl chloride; (S)-5-Oxo-1-(2-methoxyethyl)pyrrolidine-2-carboxylic acid chloride
EINECS	Contact for details

Quality Control

Our production of 2-Pyrrolidinecarbonyl Chloride, 1-(2-Methoxyethyl)-5-Oxo-, (S)- (9Ci) adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is characterized using advanced analytical techniques including HPLC, GC, NMR, and chiral analysis to confirm identity, purity, and enantiomeric excess. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation upon prolonged exposure to air. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.