Description

1-(4-Isothiocyanatobenzyl)Ethylenediamine-N,N,N',N'-Tetraacetic Acid is a bifunctional chelating agent that combines the strong metal-chelating properties of EDTA with a reactive isothiocyanate group for covalent conjugation. This compound is critical for creating stable, site-specific linkages between chelated metal ions and biomolecules such as antibodies or proteins. It is primarily needed by researchers and manufacturers in the fields of radiopharmaceuticals, in vitro diagnostics (IVD), and biomedical research for developing targeted imaging agents and therapeutic conjugates.

Application

• Radiopharmaceutical Precursor: For the chelation of diagnostic (e.g., 99mTc, 68Ga) and therapeutic (e.g., 177Lu, 90Y) radionuclides to targeting vectors.
• Antibody-Drug Conjugate (ADC) Linker: As a component in constructing ADCs where a cytotoxic payload is complexed with a metal ion.
• In Vitro Diagnostic (IVD) Reagents: Conjugation to enzymes or antibodies for use in immunoassays like ELISA.
• Magnetic Resonance Imaging (MRI) Contrast Agents: Chelation of gadolinium (Gd3+) for the development of targeted MRI probes.
• Biomolecule Immobilization: Covalent attachment of proteins or peptides to solid supports for chromatography or biosensors.
• Research Tool in Metal Biology: For studying metal ion transport, chelation therapy, and metalloprotein function.

Basic Information

Product Name	1-(4-Isothiocyanatobenzyl)Ethylenediamine-N,N,N',N'-Tetraacetic Acid
CAS No.	105394-74-9
Molecular Formula	C20H24N4O8S
Molecular Weight	480.49 g/mol
Synonyms	p-SCN-Bn-EDTA; 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid, 1-(p-isothiocyanatobenzyl) derivative; EDTA mono(p-isothiocyanatobenzyl) ester; 4-Isothiocyanatobenzyl-EDTA; SCN-Bz-EDTA; Bifunctional chelator p-SCN-Bn-EDTA; EDTA-isothiocyanate; 2,2',2'',2'''-(1-(4-Isothiocyanatobenzyl)-1,2-ethanediylbis(nitrilo(2-oxo-2,1-ethanediyl)))tetrakis-acetic acid
EINECS	Contact for details

Quality Control

Our 1-(4-Isothiocyanatobenzyl)EDTA is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistent performance for sensitive conjugation applications. A comprehensive Certificate of Analysis (COA) is provided, detailing purity, identity, and impurity profiles as determined by HPLC, NMR, and other relevant methods.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry environment. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and reactivity. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in DMSO, DMF; Slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.