Description

Doxazosin Hydrochloride CAS NO 105314-71-4 is a high-purity, selective α-1 adrenergic receptor antagonist used as a key active pharmaceutical ingredient (API). It is critical for the formulation of antihypertensive and benign prostatic hyperplasia (BPH) medications, ensuring therapeutic efficacy and batch-to-batch consistency. This compound is essential for pharmaceutical manufacturers, R&D laboratories, and contract development and manufacturing organizations (CDMOs) involved in cardiovascular and urological therapeutics.

Application

• Pharmaceutical API: Primary use as the active ingredient in tablet and capsule formulations for hypertension and BPH treatment.
• Generic Drug Manufacturing: Sourcing for the production of generic doxazosin mesylate and other salt-form medications.
• Clinical Research: Utilization in preclinical and clinical studies for cardiovascular and urological drug development.
• Reference Standard: Serves as a high-purity chemical reference standard for quality control and analytical method development.
• Formulation R&D: Used in the development of controlled-release, extended-release, and combination drug delivery systems.
• Bulk Pharmaceutical Intermediates: Acts as a critical intermediate in complex multi-step synthetic pathways for novel therapeutics.

Basic Information

Product Name	Doxazosin Hydrochloride
CAS No.	105314-71-4
Molecular Formula	C23H25N5O5 • HCl
Molecular Weight	487.94 g/mol
Synonyms	Doxazosin HCl; Doxazosin Hydrochloride Anhydrous; UK-33274; 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-[(2,3-dihydro-1,4-benzodioxin-2-yl)carbonyl]piperazine Hydrochloride; 4-Amino-2-[4-(1,4-benzodioxan-2-ylcarbonyl)piperazin-1-yl]-6,7-dimethoxyquinazoline Hydrochloride; Cardura (brand name reference); Alfadil (brand name reference)
EINECS	Contact for details

Quality Control

Our Doxazosin Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for pharmaceutical use, including compliance with relevant sections of the USP/EP monographs where applicable. A Certificate of Analysis (COA) documenting identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and regulatory support.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 1.0%; Any single impurity ≤ 0.5%
Microbial Limits	Meets USP <61> and <62> requirements

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.