Description

Naphthomycin I CAS NO 105225-02-3 is a complex ansamycin-class antibiotic isolated from *Streptomyces* species. This compound is valued for its potent biological activity, particularly as a selective inhibitor of bacterial RNA polymerase, making it a crucial reference standard and a lead compound in antimicrobial research. It is primarily utilized by pharmaceutical R&D laboratories, academic institutions, and biotechnology companies engaged in developing novel anti-infective agents and studying bacterial transcription mechanisms.

Application

• Pharmaceutical Reference Standard: Used for quality control, method validation, and identification in the analysis of ansamycin antibiotics.
• Antimicrobial Research: Serves as a key biochemical tool and lead compound in studies targeting bacterial RNA polymerase and novel antibiotic discovery.
• Mechanistic Studies: Employed in biochemical and microbiological research to investigate the inhibition of transcription and bacterial cell growth.
• Preclinical Development: Acts as a starting material or intermediate for the synthesis of analogs with improved pharmacological properties.

Basic Information

Product Name	Naphthomycin I
CAS No.	105225-02-3
Molecular Formula	C₄₀H₄₈N₂O₉
Molecular Weight	700.83 g/mol
Synonyms	Naphthomycin A; Antibiotic BMY-28438; Ansamycin BMY-28438; (3E,5E,7E,9E,11E,13E,15E,17E,19E)-20-[(2S,3S,4S,5S,6R)-4,5-Dihydroxy-6-methyl-3-(methylamino)oxan-2-yl]-5,8,13,16,19-pentamethyl-4,7,12,15,18-pentaoxo-1-oxacycloeicosa-3,5,7,9,11,13,15,17,19-nonaene-2-carboxamide; BMY 28438; BMY-28438
EINECS	Contact for details

Quality Control

Our Naphthomycin I is produced and handled under strict quality management protocols. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, MS). A Certificate of Analysis (COA) detailing batch-specific results is provided to ensure traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. This product is hygroscopic (moisture-sensitive) and light-sensitive (store away from light). For long-term storage, keep under inert atmosphere.

Specification

Item	Specification
Appearance	Yellow to orange powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.