Description

(R)-1-Benzyl-Pyrrolidine-2-Carbonyl Chloride is a chiral, non-racemic building block of significant importance in asymmetric synthesis. This compound matters as a key intermediate for introducing the (R)-pyrrolidine-2-carboxylic acid moiety, a privileged scaffold found in numerous bioactive molecules. Pharmaceutical researchers and fine chemical manufacturers need it for the development of active pharmaceutical ingredients (APIs), particularly in the areas of protease inhibitors and neurological agents.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of drug candidates targeting various diseases.
• Protease Inhibitor Development: Used in the research and production of inhibitors for enzymes like DPP-4, crucial for diabetes treatments.
• Neurological & CNS Drug Synthesis: Serves as a building block for compounds acting on neurological pathways.
• Asymmetric Catalysis Ligand Precursor: Can be utilized to develop novel chiral ligands for catalytic processes.
• Peptidomimetics & Constrained Peptides: Incorporated into the backbone of peptide-like molecules to enhance stability and bioavailability.
• Academic & Contract Research: Employed in research laboratories for method development and novel compound library synthesis.

Basic Information

Product Name	(R)-1-Benzyl-Pyrrolidine-2-Carbonyl Chloride
CAS No.	105099-19-2
Molecular Formula	C12H14ClNO
Molecular Weight	223.70 g/mol
Synonyms	(R)-1-Benzyl-2-pyrrolidinecarbonyl chloride; (R)-N-Benzylproline chloride; (R)-1-Benzyl-2-pyrrolidinecarboxylic acid chloride; (R)-N-Benzylprolyl chloride; (2R)-1-Benzyl-2-pyrrolidinecarbonyl chloride; (R)-N-Bn-Pro-Cl; (R)-Proline benzyl ester hydrochloride (precursor related); L-N-Benzylprolyl chloride (common naming variant)
EINECS	Contact for details

Quality Control

Our (R)-1-Benzyl-Pyrrolidine-2-Carbonyl Chloride is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting standards for pharmaceutical R&D and production. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.