Description

[3-[(2-Amino-6-Oxo-3H-Purin-9-Yl)Methoxy]-4-Hydroxy-Butyl]Phosphonic Acid is a high-purity, modified nucleotide analog of significant interest in advanced pharmaceutical research and development. This compound matters as a key synthetic intermediate or potential active pharmaceutical ingredient (API) for novel antiviral and anticancer therapeutics. It is primarily needed by research institutions, pharmaceutical companies, and fine chemical manufacturers engaged in the synthesis of nucleotide-based drugs, prodrug development, and targeted molecular biology applications.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of novel antiviral and anticancer nucleotide analogs.
• Prodrug Development: Used in research to create phosphonate prodrugs with enhanced cellular uptake and bioavailability.
• Biochemical Research: Serves as a substrate or inhibitor in enzymatic studies related to nucleotide metabolism and polymerase function.
• Antiviral Agent Synthesis: A precursor in the development of compounds targeting viruses such as hepatitis B (HBV), hepatitis C (HCV), and herpesviruses.
• Anticancer Drug Discovery: Investigated for its potential to interfere with DNA synthesis in rapidly dividing cancer cells.
• Fine Chemical Synthesis: Employed in custom synthesis and contract manufacturing for specialized, high-value chemical entities.

Basic Information

Product Name	[3-[(2-Amino-6-Oxo-3H-Purin-9-Yl)Methoxy]-4-Hydroxy-Butyl]Phosphonic Acid
CAS No.	104880-60-6
Molecular Formula	C10H16N5O7P
Molecular Weight	349.24 g/mol
Synonyms	9-[3-Hydroxy-4-(phosphonomethoxy)butyl]guanine; PMBG; (S)-HPMPG; (S)-9-(3-Hydroxy-2-phosphonylmethoxypropyl)guanine; (S)-HPMP Guanine; cHPMPG; Acyclic Nucleotide Phosphonate; Guanine Phosphonate Derivative
EINECS	Contact for details

Quality Control

Our [3-[(2-Amino-6-Oxo-3H-Purin-9-Yl)Methoxy]-4-Hydroxy-Butyl]Phosphonic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and heavy metals to ensure it meets the stringent requirements for pharmaceutical research. Certificates of Analysis (COA) documenting identity, purity, and quality are available for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.