Description

2'-o-Monosuccinyladenosine-3',5'-Cyclic Monophosphate Sodium Salt is a chemically modified derivative of cyclic adenosine monophosphate (cAMP), a crucial secondary messenger in cellular signaling. This succinylated analog is specifically engineered to enhance membrane permeability and stability, making it a valuable tool for modulating intracellular cAMP levels in research applications. It is primarily utilized by researchers and developers in the fields of biochemistry, molecular biology, and pharmaceutical development for studying signal transduction pathways and as a potential precursor for advanced therapeutic agents.

Application

• Biochemical Research: A critical tool for investigating cAMP-dependent protein kinase (PKA) signaling pathways and cellular response mechanisms.
• Pharmaceutical R&D: Serves as a key intermediate or reference standard in the development of novel therapeutics targeting intracellular signaling.
• Cell Biology Studies: Used to modulate intracellular cAMP concentrations to study effects on cell growth, differentiation, and metabolism.
• Enzyme Substrate: Acts as a substrate for studies involving phosphodiesterases (PDEs) and other enzymes that interact with cAMP analogs.
• Signal Transduction Probes: Employed in the design of cell-permeable probes for real-time monitoring of cAMP dynamics in live cells.
• Precursor for Conjugates: The succinyl group provides a reactive handle for conjugation to carriers, peptides, or other molecules to create targeted research compounds.

Basic Information

Product Name	2'-o-Monosuccinyladenosine-3',5'-Cyclic Monophosphate Sodium Salt
CAS No.	104809-23-6
Molecular Formula	C19H21N6O11P • xNa
Molecular Weight	Approx. 572.36 (Free acid) + Na. Contact for exact details.
Synonyms	2'-O-Succinyl-cAMP sodium salt; 2'-O-Monosuccinyladenosine cyclic 3',5'-phosphate sodium salt; N6,2'-O-Disuccinyl cAMP (common misnomer); 2'-O-(Monosuccinyl)adenosine 3',5'-cyclic monophosphate sodium; cAMP 2'-O-succinyl sodium salt; 2'-Succinyl-cAMP Na; 8-(2'-O-Succinyl)adenosine-3',5'-cyclic monophosphate sodium salt (isomer); Sc-200064A (Santa Cruz catalog reference)
EINECS	Contact for details.

Quality Control

Our 2'-o-Monosuccinyladenosine-3',5'-Cyclic Monophosphate Sodium Salt is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to rigorous analytical standards, utilizing techniques such as HPLC, NMR, and MS for verification. Specifications can be aligned with research-grade or higher purity requirements upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This compound is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, consider desiccant and under inert atmosphere to maintain stability. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.