Description

7-Methylguanosine 5'-Triphosphate Sodium Salt is a chemically modified nucleotide triphosphate analog essential for advanced biochemical and molecular biology research. This compound serves as a critical substrate for studying RNA cap structure formation, enzymatic activity, and nucleic acid metabolism. It is primarily utilized by research institutions and pharmaceutical companies engaged in enzymology, transcriptomics, and the development of novel therapeutic agents targeting RNA-related processes.

Application

• Enzymatic Substrate for RNA Capping Studies: Used as a high-purity substrate for RNA guanylyltransferases and methyltransferases to investigate mRNA cap (m7Gppp) synthesis and function.
• Biochemical Research & Assay Development: Essential for in vitro transcription systems, kinetic studies of polymerase activity, and the development of diagnostic assays.
• Pharmaceutical R&D for Antiviral Targets: Investigated in the screening and development of inhibitors targeting viral RNA capping enzymes for potential antiviral therapies.
• Synthetic Biology & Nucleotide Engineering: Employed in the synthesis of modified RNA oligonucleotides and the engineering of novel enzymatic pathways.
• Metabolic Pathway Analysis: A tool for tracing and understanding nucleotide salvage pathways and methylation processes in cellular systems.

Basic Information

Product Name	7-Methylguanosine 5'-Triphosphate Sodium Salt
CAS No.	104809-18-9
Molecular Formula	C11H17N5O14P3 • xNa
Molecular Weight	Approx. 603.1 (Free acid) - Contact for details on sodium salt form.
Synonyms	7-Methyl-GTP Sodium Salt; m7GTP Sodium Salt; N7-Methylguanosine-5'-triphosphate Sodium Salt; 7-Methylguanosine triphosphate sodium; Cap-0 analog sodium salt; mRNA cap analog; 5'-Triphosphoric acid, P1-(7-methylguanosine) ester, sodium salt
EINECS	Contact for details.

Quality Control

Our 7-Methylguanosine 5'-Triphosphate Sodium Salt is manufactured under stringent quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity verification, to ensure it meets the high standards required for sensitive research applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming specifications for purity, identity, and absence of critical impurities like nucleases.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC/UV)	Conforms to reference standard
Purity (HPLC)	≥ 95%
UV-Vis Spectrum	Characteristic of 7-methylguanosine derivatives
Water Content (KF)	≤ 5.0%
Biological Activity (Enzymatic Assay)	Suitable for use as enzyme substrate

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.