Description

2'-o-Monosuccinyladenosine-3',5'-Cyclic Monophosphate Sodium Salt is a chemically modified derivative of cyclic adenosine monophosphate (cAMP), a crucial secondary messenger in cellular signaling. This succinylated analog is specifically designed for enhanced membrane permeability and stability, making it a valuable tool for modulating intracellular cAMP levels in research. It is primarily utilized by researchers in biochemistry, molecular biology, and pharmacology for studying signal transduction pathways, enzyme regulation, and cellular responses.

Application

• Biochemical Research: A key reagent for investigating cAMP-dependent protein kinase (PKA) activation and downstream signaling cascades in cell-based assays.
• Pharmaceutical Development: Used as a reference standard or an experimental tool compound in drug discovery programs targeting G-protein-coupled receptors (GPCRs) and phosphodiesterases.
• Cell Physiology Studies: Employed to artificially elevate intracellular cAMP concentrations to study effects on metabolism, gene expression, and ion channel function.
• Enzyme Substrate/Inhibitor Studies: Serves as a modified substrate for studying the specificity and kinetics of phosphodiesterases and other nucleotide-metabolizing enzymes.

Basic Information

Product Name	2'-o-Monosuccinyladenosine-3',5'-Cyclic Monophosphate Sodium Salt
CAS No.	104809-11-2
Molecular Formula	C19H21N5O11P • xNa
Molecular Weight	Approx. 581.36 (Free acid)
Synonyms	2'-O-Succinyl-cAMP sodium salt; 2'-O-Monosuccinyladenosine cyclic 3',5'-(hydrogen phosphate) sodium salt; N6,2'-O-Disuccinyl cAMP; 2'-O-Succinyladenosine 3',5'-cyclic monophosphate sodium salt; Succinyl cAMP; 2'-O-(Monosuccinyl)adenosine-3',5'-cyclic monophosphoric acid sodium salt; cAMP 2'-O-succinyl sodium salt
EINECS	Contact for details

Quality Control

Our 2'-o-Monosuccinyladenosine-3',5'-Cyclic Monophosphate Sodium Salt is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, MS). We provide comprehensive Certificates of Analysis (COA) detailing assay, impurity profile, and residual solvent data to ensure it meets the exacting standards required for life science research.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This compound is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, consider desiccant and under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Solvent Residues (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.