Description

7-(3-Trichloro-2-Hydroxypropane)Deoxyguanosine is a modified nucleoside derivative, specifically an adduct of deoxyguanosine. This compound is of significant interest in biochemical and toxicological research due to its role as a marker for DNA damage. It serves as a critical reference standard and research reagent for scientists investigating the mechanisms of genotoxicity, carcinogenesis, and DNA repair pathways. Professionals in pharmaceutical R&D, analytical testing laboratories, and academic institutions utilize this high-purity material to ensure accurate and reliable experimental results.

Application

• Biomarker Research: Used as a definitive analytical standard for the detection and quantification of DNA adducts formed by specific alkylating agents or environmental toxins.
• Toxicology Studies: Essential for in vitro and in vivo studies aimed at understanding the genotoxic and mutagenic potential of chemical exposures.
• Mechanistic Biochemistry: Employed to study the structural and functional consequences of specific DNA lesions on replication and transcription.
• Analytical Method Development: Serves as a critical calibrant and reference material for developing and validating sensitive analytical techniques such as LC-MS/MS and HPLC.
• Cancer Research: Used in investigations linking specific DNA damage products to the initiation and progression of various cancers.
• Quality Control in Pharma: Acts as a reference compound for ensuring the purity and safety of pharmaceutical products by screening for potential genotoxic impurities.

Basic Information

Product Name	7-(3-Trichloro-2-Hydroxypropane)Deoxyguanosine
CAS No.	104783-28-0
Molecular Formula	C13H16Cl3N5O5
Molecular Weight	428.65 g/mol
Synonyms	7-(3-Trichloro-2-hydroxypropyl)deoxyguanosine; N7-(3-Trichloro-2-hydroxypropyl)-2'-deoxyguanosine; 1-(2-Deoxy-β-D-erythro-pentofuranosyl)-7-(3-trichloro-2-hydroxypropyl)guanine; 7-(3,3,3-Trichloro-2-hydroxypropyl)-2'-deoxyguanosine; DNA Adduct Standard (Trichloropropanol-derived); Deoxyguanosine Trichloropropanol Adduct; TCHP-dG Adduct
EINECS	Contact for details

Quality Control

Every batch of 7-(3-Trichloro-2-Hydroxypropane)Deoxyguanosine is manufactured and analyzed under strict quality management systems. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality protocols are designed to meet the stringent requirements of research and analytical applications, ensuring reliable and reproducible performance in your laboratory.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Individual impurity ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.