Description

Benzoyl Chloride, 4-(3-Chloro-3H-Diazirin-3-Yl)- (9Ci) is a specialized diazirine-functionalized benzoyl chloride derivative, a key building block in photochemistry and chemical biology. Its core value lies in its ability to act as a photoactivatable crosslinking agent, enabling the study of protein-protein interactions and ligand-receptor binding under controlled UV light. This compound is essential for researchers and manufacturers in pharmaceutical development, proteomics, and advanced materials science who require precise, irreversible labeling of biomolecules.

Application

• Photoaffinity Labeling (PAL): A critical reagent for creating covalent bonds between bioactive molecules (e.g., drugs, peptides) and their target proteins upon UV irradiation, used to map binding sites.
• Chemical Proteomics: Employed in activity-based protein profiling (ABPP) to identify and characterize enzyme function within complex biological systems.
• Bioconjugation & Protein Engineering: Facilitates the site-specific modification of proteins and antibodies for the development of diagnostics, targeted therapies, and biocatalysts.
• Polymer & Surface Functionalization: Used to introduce photoreactive groups onto polymer backbones or material surfaces for creating smart, responsive coatings and adhesives.
• Organic Synthesis Intermediate: Serves as a precursor for synthesizing more complex diazirine-containing probes and ligands in medicinal chemistry.

Basic Information

Product Name	Benzoyl Chloride, 4-(3-Chloro-3H-Diazirin-3-Yl)- (9Ci)
CAS No.	104745-66-6
Molecular Formula	C8H4Cl2N2O
Molecular Weight	215.04 g/mol
Synonyms	4-(3-Chloro-3H-diazirin-3-yl)benzoyl chloride; 3-Chloro-3-(4-(chlorocarbonyl)phenyl)diazirine; p-(3-Chloro-3H-diazirin-3-yl)benzoyl chloride; Diazirine-Benzoyl Chloride; Photoactivatable Benzoyl Chloride; PAL Crosslinker; Benzoyl chloride, p-(3-chloro-3H-diazirin-3-yl)-; 4-(Diazirin-3-yl)benzoyl chloride derivative
EINECS	Contact for details

Quality Control

Every batch of our Benzoyl Chloride, 4-(3-Chloro-3H-Diazirin-3-Yl)- (9Ci) is produced and handled under strict quality management protocols to ensure high purity, lot-to-lot consistency, and optimal photoreactivity. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, identity, and functional performance are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place (recommended 2-8°C or as specified on the label) under an inert atmosphere if necessary. This compound is hygroscopic (moisture-sensitive) and light-sensitive; prolonged exposure to air, moisture, or light will degrade its photoreactive functionality.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Water Content (KF)	≤ 0.5%
Photoactivation Wavelength	~350-365 nm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.