Description

9-(4-Hydroxy-2-Buten-1-Yl)Guanine is a chemically modified guanine derivative, a key building block in nucleoside chemistry. This compound matters for its role as a versatile intermediate in the synthesis of novel antiviral and anticancer nucleoside analogs. Pharmaceutical R&D and fine chemical synthesis laboratories need it to develop next-generation therapeutic agents targeting viral polymerases and cellular enzymes. Its structural features make it a valuable precursor for probing biochemical pathways and creating modified nucleic acids.

Application

• Pharmaceutical Intermediate: Critical precursor in the synthesis of experimental antiviral and antineoplastic nucleoside drugs.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies, particularly those involving polymerases and kinases.
• Proteomics & Molecular Biology: Serves as a modified base for creating probes and tools to study DNA/RNA interactions and repair mechanisms.
• Fine Chemical Synthesis: Building block for constructing complex nucleoside libraries for high-throughput screening in drug discovery.
• Academic Research: Employed in universities and research institutes for fundamental studies in medicinal chemistry and chemical biology.

Basic Information

Product Name	9-(4-Hydroxy-2-Buten-1-Yl)Guanine
CAS No.	104715-61-9
Molecular Formula	C9H11N5O2
Molecular Weight	221.22 g/mol
Synonyms	9-[(4-Hydroxy-2-buten-1-yl)]guanine; 9-(4-Hydroxybut-2-en-1-yl)guanine; Guanine, 9-[(4-hydroxy-2-buten-1-yl)]-; 9-(4-Hydroxy-2-butenyl)guanine; 9-(trans-4-Hydroxy-2-buten-1-yl)guanine; 9-(cis/trans-4-Hydroxy-2-buten-1-yl)guanine; H2BuG; 9-(4'-Hydroxy-2'-butenyl)guanine
EINECS	Contact for details

Quality Control

Our 9-(4-Hydroxy-2-Buten-1-Yl)Guanine is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.