Description

3,3'-Dithiobis(3'-o-6-(Propionylamino)Hexanoyl)Adenosine 5'-Triphosphate is a specialized, chemically modified nucleotide analog designed for advanced biochemical research and development. This compound is engineered to introduce a cleavable disulfide linkage and a reactive propionylaminohexanoyl spacer arm, enabling its use in controlled conjugation and cross-linking studies. It is primarily utilized by researchers and manufacturers in the fields of bioconjugation, proteomics, and nucleic acid chemistry for applications requiring site-specific labeling and reversible bond formation.

Application

• Bioconjugation Reagent: For the site-specific labeling of proteins, peptides, and antibodies via cleavable disulfide bonds.
• Cross-linking Studies: Used in structural biology to investigate protein-protein or protein-nucleic acid interactions with reversible linkages.
• Proteomics Research: As a tool compound for affinity purification, pull-down assays, and mass spectrometry-based target identification.
• Nucleotide Analog Synthesis: Serves as a key intermediate or building block for synthesizing novel, functionalized ATP analogs.
• Diagnostic Assay Development: For creating sensitive detection systems in ELISA or lateral flow assays that require controlled release mechanisms.
• Drug Delivery Systems: Potential application in the design of prodrugs or targeted delivery vehicles where a redox-sensitive trigger is needed.

Basic Information

Item	Detail
Product Name	3,3'-Dithiobis(3'-o-6-(Propionylamino)Hexanoyl)Adenosine 5'-Triphosphate
CAS No.	104693-47-2
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Disulfide-linked ATP analog; 3,3'-Dithiobis(adenosine 5'-triphosphate) derivative; Propionylaminohexanoyl-ATP disulfide; ATP-SS-N-propionylamide; Modified ATP with cleavable linker; Redox-sensitive ATP analog; Adenosine-5'-triphosphate, 3,3'-dithiobis[3'-O-[6-[(1-oxopropyl)amino]-1-oxohexyl]-; Biotinylation-grade ATP analog (potential trade name context)
EINECS	Contact for details

Quality Control

Our production of 3,3'-Dithiobis(3'-o-6-(Propionylamino)Hexanoyl)Adenosine 5'-Triphosphate adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity, critical for sensitive research applications. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.