Description

Doretinel CAS NO 104561-36-6 is a synthetic retinoid compound, a member of the vitamin A analog family. This compound is significant for its role in modulating cell differentiation and proliferation, making it a valuable research chemical in the life sciences sector. It is primarily utilized by pharmaceutical R&D departments and academic research institutions investigating dermatological conditions, oncology, and cellular signaling pathways.

Application

• Pharmaceutical Research & Development: Serves as a key intermediate or active reference standard in the development of novel retinoid-based therapeutics.
• Dermatology Studies: Used in preclinical research to study effects on skin cell regeneration, acne, psoriasis, and photoaging.
• Oncology Research: Investigated for its potential effects on cancer cell growth, differentiation, and apoptosis in various in vitro and in vivo models.
• Biochemical Research: Employed as a ligand to study nuclear receptor (e.g., RAR, RXR) interactions and gene expression regulation.
• Reference Standard: Used in analytical laboratories for method development, validation, and quality control testing of related pharmaceutical products.
• Cosmeceutical Ingredient Research: Explored for potential application in high-end skincare formulations targeting cellular renewal.

Basic Information

Product Name	Doretinel
CAS No.	104561-36-6
Molecular Formula	C22H28O3
Molecular Weight	340.46 g/mol
Synonyms	4-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethenyl]benzoic Acid; Ro 13-7410; TTNPB (4-[(E)-2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl]benzoic Acid) analog; Arotinoid; Retinoid analog; Synthetic retinoid; Benzoic acid, 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthalenyl)ethenyl]-
EINECS	Contact for details

Quality Control

Our Doretinel is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and residual solvent analysis. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. Keep away from oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.