Description

L-Proline, 1-(Chlorocarbonyl)-3-Ethyl-, trans- (9Ci) CAS NO 104561-27-5 is a high-purity, non-natural proline derivative featuring a reactive acid chloride group. This compound matters as a versatile chiral building block for the synthesis of complex molecules, offering precise stereochemical control. It is primarily needed by pharmaceutical and agrochemical research organizations for developing active pharmaceutical ingredients (APIs), peptide mimetics, and novel bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of protease inhibitors, renin inhibitors, and other small-molecule therapeutics.
• Peptide Chemistry: Used for the site-specific introduction of modified proline residues to enhance peptide stability, bioavailability, and biological activity.
• Agrochemical Research: Serves as a precursor in the development of novel herbicides and fungicides with chiral centers.
• Chemical Biology & Proteomics: Employed as a tool compound for studying enzyme mechanisms and designing activity-based probes.
• Material Science: Potential monomer for creating specialized polymers with unique structural properties.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of client-specific advanced intermediates under cGMP conditions.

Basic Information

Product Name	L-Proline, 1-(Chlorocarbonyl)-3-Ethyl-, trans- (9Ci)
CAS No.	104561-27-5
Molecular Formula	C8H12ClNO3
Molecular Weight	205.64 g/mol
Synonyms	(2S,3S)-1-[(Chlorocarbonyl)-3-ethylpyrrolidine-2-carboxylic acid; trans-1-Chlorocarbonyl-3-ethyl-L-proline; (2S,3S)-3-Ethyl-1-(chlorocarbonyl)pyrrolidine-2-carboxylic acid; 3-Ethyl-L-proline-1-carbonyl chloride; 1-Carboxy-3-ethyl-L-proline chloride; L-Proline, 1-(chlorocarbonyl)-3-ethyl-, (2S,3S)-; 104561-27-5
EINECS	Contact for details

Quality Control

Our L-Proline, 1-(Chlorocarbonyl)-3-Ethyl-, trans- (9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing specifications such as assay, enantiomeric excess, and impurity profiles. Our quality commitment supports applications in regulated environments, including pharmaceutical R&D.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions. Keep away from strong acids and organic solvents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.