Description

D-Proline, 1-(Chlorocarbonyl)-3-Ethyl-, trans- (9Ci) is a specialized, non-proteinogenic amino acid derivative featuring a chlorocarbonyl group and an ethyl substituent on the proline ring. This compound serves as a high-value chiral building block and intermediate in advanced organic synthesis, where its defined stereochemistry is critical for constructing complex molecular architectures. It is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, as well as by fine chemical manufacturers producing custom peptides and catalysts.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the research and development of new drug candidates, particularly in protease inhibitor and peptidomimetic programs.
• Peptide Chemistry: Used in the synthesis of modified peptides and peptoids, where the D-configuration and ethyl side chain introduce conformational constraints and alter biological activity.
• Asymmetric Catalysis: Serves as a precursor for chiral ligands or organocatalysts used in enantioselective synthesis.
• Agrochemical Research: Intermediate in the development of novel, stereochemically-defined pesticides and herbicides.
• Chemical Biology Probes: Building block for creating labeled or tagged amino acid analogs used in mechanistic studies and biochemical assays.
• Academic & Contract Research: Essential material for methodological development in synthetic organic chemistry within university and CRO laboratories.

Basic Information

Product Name	D-Proline, 1-(Chlorocarbonyl)-3-Ethyl-, trans- (9Ci)
CAS No.	104561-26-4
Molecular Formula	C8H12ClNO3
Molecular Weight	205.64 g/mol
Synonyms	(2R,3S)-1-[(Chlorocarbonyl)-3-ethyl-2-pyrrolidinecarboxylic acid; trans-1-Chlorocarbonyl-3-ethyl-D-proline; (2R,3S)-3-Ethyl-1-[(chloroformyl)]proline; D-1-(Chlorocarbonyl)-3-ethylproline; 1-Carboxy-3-ethyl-D-proline chloride; 3-Ethyl-D-proline-1-carbonyl chloride; 104561-26-4; (2R,3S)-1-(Chlorooxomethyl)-3-ethylpyrrolidine-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our D-Proline derivative is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the exacting standards required for advanced synthetic applications. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to prevent decomposition. Keep away from strong acids and organic solvents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% de
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.