Description

8,5'-Cyclo-2'-Deoxyguanosine is a structurally unique cyclonucleoside derivative of deoxyguanosine. This compound is of significant interest in biochemical and pharmaceutical research due to its role as a biomarker for oxidative DNA damage. It is primarily utilized by research institutions and pharmaceutical companies engaged in studies related to oxidative stress, DNA repair mechanisms, and the development of analytical standards for detecting DNA lesions.

Application

• Biomarker Research: Serves as a critical standard and reference material for the detection and quantification of oxidative DNA lesions in biological samples.
• Mechanistic Studies: Used in biochemical research to investigate the mechanisms of DNA damage induced by reactive oxygen species (ROS) and ionizing radiation.
• Analytical Method Development: Employed as a high-purity standard in the development and validation of sensitive analytical techniques such as LC-MS/MS and HPLC for DNA adductomics.
• Pharmaceutical R&D: Supports drug discovery programs focused on oncology and diseases linked to oxidative stress by helping to evaluate the genotoxic profiles of new chemical entities.
• Toxicology Studies: Applied in environmental and chemical toxicology to assess the genotoxic impact of various agents by measuring the formation of specific DNA adducts.
• Academic Research: A key reagent for universities and research laboratories studying nucleic acid chemistry, radiobiology, and free radical biology.

Basic Information

Product Name	8,5'-Cyclo-2'-Deoxyguanosine
CAS No.	104504-22-5
Molecular Formula	C10H11N5O4
Molecular Weight	265.23 g/mol
Synonyms	8,5'-Cyclo-2'-deoxyguanosine; 8,5'-cdG; 8,5'-Cyclo-dG; 5',8-Cyclo-2'-deoxyguanosine; (5'R)-8,5'-Cyclo-2'-deoxyguanosine; (5'S)-8,5'-Cyclo-2'-deoxyguanosine; 8,5'-Cyclo-2'-deoxyguanosine (R and S diastereomers); Oxidized guanine nucleoside
EINECS	Contact for details

Quality Control

Our 8,5'-Cyclo-2'-Deoxyguanosine is produced under stringent quality management protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, typically determined by advanced chromatographic and spectroscopic methods. We adhere to relevant industry standards for research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Individual impurity ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.