Description

Bicyclo[3.2.1]Octane-1-Carbonyl Chloride, 8,8-Dimethyl-2-Oxo-, (1S)- (9Ci) is a high-purity, chiral bicyclic building block featuring a reactive acid chloride functional group. This compound is critical for the synthesis of complex, stereochemically defined molecules, offering a rigid, three-dimensional scaffold that is highly sought after in advanced pharmaceutical research. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients with targeted biological properties.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of novel drug candidates, particularly in central nervous system (CNS) and antiviral therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides with specific stereochemical requirements for enhanced efficacy.
• Asymmetric Catalysis Ligand Precursor: Serves as a starting material for synthesizing sophisticated chiral ligands and organocatalysts.
• Material Science Research: Employed in the creation of specialty polymers and advanced organic materials with unique structural properties.
• Chemical Biology Probes: Utilized to build molecular probes for studying enzyme mechanisms and protein-ligand interactions.
• Custom Synthesis & Contract Manufacturing: A vital component for CDMOs (Contract Development and Manufacturing Organizations) offering bespoke chemical synthesis services.

Basic Information

Product Name	Bicyclo[3.2.1]Octane-1-Carbonyl Chloride, 8,8-Dimethyl-2-Oxo-, (1S)- (9Ci)
CAS No.	104477-76-1
Molecular Formula	C11H15ClO2
Molecular Weight	214.69 g/mol
Synonyms	(1S)-8,8-Dimethyl-2-oxobicyclo[3.2.1]octane-1-carbonyl chloride; (1S)-2-Oxo-8,8-dimethylbicyclo[3.2.1]octane-1-carbonyl chloride; (-)-8,8-Dimethyl-2-oxobicyclo[3.2.1]octane-1-carbonyl chloride; (1S)-Camphor-1-carbonyl chloride derivative; L-Bicyclo[3.2.1]octane carbonyl chloride; (1S,5R)-8,8-Dimethyl-2-oxobicyclo[3.2.1]octane-1-carbonyl chloride
EINECS	Contact for details

Quality Control

Our Bicyclo[3.2.1]Octane-1-Carbonyl Chloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity, essential for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, enantiomeric excess, and impurity profiles. Our quality systems are designed to support cGMP (current Good Manufacturing Practice) compliance for pharmaceutical development, and we can tailor specifications to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis. Keep away from strong bases and sources of ignition.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.