Description

2-Amino-N2-Isobutyryl-2'-Deoxyadenosine is a chemically modified nucleoside derivative, specifically engineered for advanced research and development in medicinal chemistry and oligonucleotide synthesis. This compound serves as a critical building block for the creation of modified DNA and RNA sequences, enabling the study of nucleic acid structure, function, and therapeutic potential. It is primarily utilized by pharmaceutical R&D teams, biotechnology companies, and academic research institutions focused on antisense technology, siRNA development, and novel therapeutic agent discovery.

Application

• Oligonucleotide Synthesis: A key phosphoramidite precursor for the solid-phase synthesis of modified antisense oligonucleotides and siRNAs.
• Medicinal Chemistry Research: Used in the design and development of nucleoside-based prodrugs and novel therapeutic agents targeting viral infections and genetic disorders.
• Biochemical Probes: Acts as a substrate or inhibitor in enzymatic studies to investigate the mechanisms of DNA polymerases and repair enzymes.
• Structural Biology Studies: Incorporated into DNA strands for X-ray crystallography or NMR studies to analyze nucleic acid conformation and protein-nucleic acid interactions.
• Diagnostic Assay Development: Employed in the creation of labeled probes for sensitive detection systems in molecular diagnostics.

Basic Information

Product Name	2-Amino-N2-Isobutyryl-2'-Deoxyadenosine
CAS No.	104477-50-1
Molecular Formula	C15H20N6O4
Molecular Weight	348.36 g/mol
Synonyms	2'-Deoxy-2-amino-N2-isobutyryladenosine; N2-Isobutyryl-2-amino-2'-deoxyadenosine; 2-Amino-2'-deoxy-N2-isobutyryladenosine; 2'-Deoxyadenosine, 2-amino-N2-(2-methylpropanoyl)-; dA(ib) (common abbreviation); Isobutyryl-protected 2-aminodeoxyadenosine; 2-N-Isobutyryl-2-aminodeoxyadenosine
EINECS	Contact for details

Quality Control

Our 2-Amino-N2-Isobutyryl-2'-Deoxyadenosine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent controls for moisture and residual solvents. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided to ensure traceability and compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.