Description

2'-Deoxy-2'-Methyleneadenosine is a chemically modified nucleoside analog of significant interest in advanced pharmaceutical research and development. Its unique structure, featuring a methylene bridge at the 2'-position, makes it a valuable intermediate for probing biochemical pathways and developing novel therapeutic agents. This compound is primarily utilized by research institutions and pharmaceutical companies engaged in antiviral and anticancer drug discovery programs.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel nucleoside-based antiviral and anticancer prodrugs.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to investigate the mechanisms of DNA/RNA polymerases and related enzymes.
• Antiviral Agent Development: Serves as a precursor for compounds targeting viral replication, particularly for viruses like hepatitis B (HBV) and certain retroviruses.
• Anticancer Agent Development: Investigated for its potential to be incorporated into oligonucleotides or prodrugs designed to selectively target and disrupt cancer cell proliferation.
• Medicinal Chemistry: A crucial scaffold for structure-activity relationship (SAR) studies to optimize potency, selectivity, and metabolic stability of drug candidates.

Basic Information

Product Name	2'-Deoxy-2'-Methyleneadenosine
CAS No.	104409-41-8
Molecular Formula	C11H13N5O3
Molecular Weight	263.25 g/mol
Synonyms	2'-Deoxy-2'-methylene adenosine; 2'-C-Methyleneadenosine; 9-[(2R,3R,4R,5R)-3,4-Dihydroxy-5-(hydroxymethyl)-3-methylenetetrahydrofuran-2-yl]-9H-purin-6-amine; MDL 28,050; 2'-Deoxy-2'-methylideneadenosine; 2'-Deoxy-2'-methylene-Adenosine; 2'-Deoxy-2'-methylenadenosine; DMDNA
EINECS	Contact for details

Quality Control

Our 2'-Deoxy-2'-Methyleneadenosine is produced under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry guidelines to support our clients' regulatory and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥97.0%
Water Content (KF)	≤2.0%
Related Substances (HPLC)	Total impurities ≤3.0% Any single impurity ≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.