Description

R(+)-1-(Pentafluorophenyl)Ethanol is a high-value, chiral fluorinated alcohol building block essential for advanced organic synthesis. Its unique structure, featuring a pentafluorophenyl group and a stereogenic center, makes it a critical intermediate for developing novel pharmaceuticals and agrochemicals with enhanced metabolic stability and bioavailability. This compound is primarily sought by research and development chemists in the pharmaceutical, agrochemical, and specialty materials industries for applications in asymmetric synthesis, ligand development, and the creation of fluorinated analogs of bioactive molecules.

Application

• Pharmaceutical Intermediate: Key chiral precursor for the synthesis of active pharmaceutical ingredients (APIs), particularly in developing CNS agents, anti-inflammatory drugs, and enzyme inhibitors.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and pesticides where the fluorinated aromatic ring improves lipophilicity and target binding.
• Chiral Ligand & Catalyst Development: Serves as a starting material for synthesizing novel chiral ligands and organocatalysts used in asymmetric hydrogenation and carbon-carbon bond formation.
• Material Science Research: Building block for fluorinated liquid crystals, polymers, and specialty materials requiring specific optical or electronic properties.
• Academic & Contract Research: Utilized in university and CRO laboratories for methodological development in fluoroorganic chemistry and stereoselective synthesis.

Basic Information

Product Name	R(+)-1-(Pentafluorophenyl)Ethanol
CAS No.	104371-21-3
Molecular Formula	C8H5F5O
Molecular Weight	212.12 g/mol
Synonyms	(R)-(+)-1-(Pentafluorophenyl)ethanol; (R)-1-(Perfluorophenyl)ethanol; (R)-α-Methyl-2,3,4,5,6-pentafluorobenzyl alcohol; (R)-Pentafluorophenylethanol; R(+)-Pentafluorophenylethanol; (R)-PFE; (R)-1-(C6F5)CH(OH)CH3; (R)-Pentafluorophenyl methyl carbinol
EINECS	Contact for details

Quality Control

Our R(+)-1-(Pentafluorophenyl)Ethanol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for research and process development. A detailed Certificate of Analysis (COA) providing specifications for identity, purity (assay and enantiomeric excess), and impurities is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in the original packaging or an amber vessel until use.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.