Description

S(-)-1-(Pentafluorophenyl)Ethanol is a high-value chiral fluorinated building block, specifically the (S)-enantiomer of 1-(pentafluorophenyl)ethanol. This compound matters as a critical intermediate for synthesizing advanced pharmaceuticals and agrochemicals, where its defined stereochemistry and unique pentafluorophenyl group impart specific biological activity and metabolic stability. It is primarily needed by research and development chemists and process engineers in the pharmaceutical, agrochemical, and advanced materials sectors for creating novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key chiral precursor for the synthesis of active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and anti-inflammatory drug candidates.
• Agrochemical Synthesis: Building block for developing novel herbicides, fungicides, and insecticides with enhanced efficacy and environmental profile.
• Ligand and Catalyst Development: Used in asymmetric synthesis to create chiral ligands and organocatalysts for stereoselective transformations.
• Advanced Material Research: Monomer or functional group for specialty polymers and liquid crystals, leveraging the properties of the fluorinated aromatic ring.
• Chemical Biology Probes: Employed in medicinal chemistry for structure-activity relationship (SAR) studies and as a probe in biochemical assays.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects at various scales.

Basic Information

Item	Details
Product Name	S(-)-1-(Pentafluorophenyl)Ethanol
CAS No.	104371-20-2
Molecular Formula	C8H5F5O
Molecular Weight	212.12 g/mol
Synonyms	(S)-1-(Pentafluorophenyl)ethanol; (S)-α-(Pentafluorophenyl)ethanol; (S)-Pentafluorophenylmethylcarbinol; (S)-1-(Perfluorophenyl)ethanol; (S)-PFE; (S)-(-)-1-(Pentafluorophenyl)ethyl alcohol; (S)-Pentafluorophenylethanol; (S)-1-(2,3,4,5,6-Pentafluorophenyl)ethanol
EINECS	Contact for details

Quality Control

Our S(-)-1-(Pentafluorophenyl)Ethanol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity assessment by HPLC, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, the container should be amber glass or otherwise opaque.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.